Evaluation of Effectiveness of Different Dosage of Neostigmine in Combination with Metoclopramide, on Gastric Residual Volume, in Enteral Nutrition, in Hospitalized Patients in Intensive Care Unit

The aim of this study was to evaluate the effect of different doses of Neostigmine in combination with Metoclopramide , on the gastric residual volume of trauma patients in the intensive care unit will be done that under enteral nutrition via NG.Tube or OG.Tube.

This study is 165 patients (in three groups of 55) traumatized patients referring to Rasoul-E Akram Hospital in Tehran divided into three groups A, B and C using block randomized method

Patients who are traumatized and referring to Rasoul-E Akram hospital in Tehran and admitted to the intensive care unit. The design of the study is a double-blind, randomized controlled trial. Patients and physicians who examine the status of the patients will be blinded to the intervention type.

Enteral nutrition feeding; after three hours from the last gavage gastric residual volume ≥50% and age 18-60 are inclusion criteria and exclusion criteria are diabetes mellitus disease; heart rate <60 and systolic blood pressure <90.

(Gold standard group): Metoclopramide will be prescribed five milligrams in every eight hours by IV.slow method during one minute. In addition, one milligram of NASTIGMINE dose in dilute solution of 100 cc Normal Saline and infusion takes in time 60 minutes. The gavage will be done three hours after the completion of the Neostigmine infusion. patients will be get 300 cc Gavage every three hours. (Intervention group 1): Metoclopramide will be prescribed five milligrams in every eight hours by IV.slow method during one minute. In addition, one and a half milligrams of NASTIGMINE dose in dilute solution of 100 cc Normal Saline and infusion takes in time 60 minutes. The gavage will be done three hours after the completion of the Neostigmine infusion. patients will be get 300 cc Gavage every three hours. (Intervention group 2): Metoclopramide will be prescribed five milligrams in every eight hours by IV.slow method during one minute. In addition, two milligrams of NASTIGMINE dose in dilute solution of 100 cc Normal Saline and infusion takes in time 60 minutes. The gavage will be done three hours after the completion of the Neostigmine infusion. patients will be get 300 cc Gavage every three hours

The gastric remaining volume after three hours is the primary outcome.

Vice chancellor for research, Iran University of Medical Sciences

Traumatized patients divided into three groups A, B and C using block randomized method. In this study a person who is not in the study process after the admission of the patient, allocated the relevant intervention to each patient with the relevant block and notifies the director of the research team.

This is a double blind study that patients or their companions after verifying the informed consent of the study, will be blind the type of intervention. Physicians and carers of patients which examines the clinical status of patients will be blind to the type of intervention that patients are taking.