The Effect of curcumin on oxidative indices, inflammatory factors and Sequential Organ Failure Assessment Score in patients with systemic inflammatory response syndrome

1- Determining and comparing the effect of curcumin supplementation on oxidative indices in patients with systemic inflammatory response syndrome (SIRS). 2- Determining and comparing the effect of curcumin supplementation on inflammatory indicators in patients with SIRS. 3- Determining and comparing the effect of curcumin supplementation on the SOFA index in patients with SIRS

In this study 40 patients aged 18-50 years with systemic inflammatory response syndrome (SIRS positive) are selected in ICU Participants are randomly assigned to RAS software by random block method in one of two groups of curcumin or a control group.

After selecting the samples from Imam Reza Tabriz Hospital, the patients are placed in one of two curcumin and control groups. On the first, fifth and tenth day of the study,the SOFA questionnaire, nutritional status will be completed for the patients.Also, 5 cc of blood will be taken from the patients

Inclusions criteria for the study: Critically ill ICU patients with APACHE II score of 15-30; Positive SIRS; Aged over 18 and under the age of 60 years; Hospitalization at least 10 days in ICU; Recipients of enteral nutrition formula; Exclusions criteria: Parenteral feeding; Intolerance to enteral feeding and gavage solution; Patient is waiting for death in the 24 future hourse; HIV positive patient; Pregnant and lactating women; Ileus; Mellitus diabetes; Short bowel syndrome; Pancreatitis; Immune disorders

The intervention group (two 80 mg capsules) will receive 160 mg / day curcumin The control group will receive the usual formulation without supplementation.

1- Assessment of oxidative indices 2- Assessment of inflammatory factors 3. Assessment of SOFA index 4. Assessment of nutrition status 5. Assessment of biochemical factors

Publishing some of the study results and updating the modified factors related to the disease

With Using of RAS software in two groups of 20 people

Introduction Sepsis is a severe reaction and excessive immune response to infection, which can lead to tissue damage, organ dysfunction, and death. This study aimed to investigate the protective effect of curcumin on inflammatory factors and clinical outcomes in patients with sepsis. Methods This randomized clinical trial was conducted on 40 patients with sepsis aged 18–55 years, who received 160 mg of nano curcumin supplement (two capsules 80 mg) or placebo (two capsules of placebo) via a nasogastric tube for 10 days. Sequential organ failure assessment (SOFA) was evaluated on days 1 and 10. Serum levels of inflammatory factors of procalcitonin (PCT), Interleukin- 6 (IL-6), tumor necrosis factor-alpha, (TNF-α),and high-sensitive C-reactive protein (hs-CRP) were measured before the beginning of the intervention and on days 5 and 10. Length of hospital stay, mortality rate, and mechanical ventilation duration was compared between groups. Results Serum levels of PCT (p = 0.002), IL-6 (p = 0.012), and TNF-α (p = 0.026) in the nano curcumin group on day 10 were significantly lower than in the placebo group. The duration of mechanical ventilation in the nano curcumin group was remarkably (p = 0.038) lower than in the placebo group. Also, the SOFA score significantly (p = 0.005) decreased in the intervention group compared to the placebo group. No significant difference was observed in the mean serum levels of hs-CRP, duration of the intensive care unit stay, and mortality rates between the study groups. Conclusions Our study indicated that nano curcumin could decrease the levels of inflammatory factors, duration of mechanical ventilation, and organ failure in critically ill patients.