Comparison of the combination of dexmedethomidine and fentanyl with midazolam and fentanyl in induction of sedation and analgesia for reduction of distal radial fracture in the emergency department

Determination of the efficacy of dexmedethomidine and fentanyl with midazolam and fentanyl in induction of sedation and analgesia to reduction of distal radial fracture in the emergency department

This randomized clinical trial was conducted in emergency department of Shahid Beheshti University of Medical Sciences. The trial phase was 1 and 2. All patients who referred to the emergency department with a distal radial fracture and who were between the ages of 18 and 60 years were included in the study. The sample size was about 40 people. Patients were randomly assigned into 2 groups and their demographic information was recorded and for induction of sedation and analgesia the first group was given midazolam and fentayl and the second group received dexmedethomidine and fentanyl. And the outcomes were measured before, during and after the procedure and recorded in both groups.

Patients with a distal radial fracture who were referred to the emergency department of Imam Hossein and Haft e Tir Hospital were included. The study was conducted as a single-blind as it was not possible to double blinding because the difference in the method of administration of the drug. Clinical investigator and clinical observer were aware of the study but the Patient and outcome evaluator and statistical analyzer were unaware of the study.

All patients between the ages of 18 and 60 who referred to the emergency department with Radius distal fracture were included. Patients under the age of 18 and over the age of 60 years, patients with a history of antihypertensive or antihistaminic use, patients with severe accompanying injuries such as head trauma and GCS <15, severe chest trauma, Cervical spine trauma with unstable fracture, and patients with mental retardation, hemodynamically unstable patients , patients with history of heart disease (cardiac block and bradycardia), pregnant women, Opioids addiction and substance abuse, and history Sensitivity to any of the medications that should be used.

Patients with distal radial fracture who referred to the emergency department from each two genders

The variables studied included: age, sex, severity of pain, blood pressure, heart rate, respiratory rate, arterial oxygen saturation, apnea, bradycardia, nausea and vomiting

ُSimple Randomization

In this study, the researcher and clinical caregiver (professor and assistant) were not blinded due to the difference in method of each drug administration and also the need for knowledge about the type of administrating drug to deal with their possible side effects and complication, But the outcome elevator (the second senior assistant) and the data analyzer were unaware of the study