The aim of study is to assess the effectiveness of peer education on self-esteem, perceived vulnerability and performance towards prevention of HIV and hepatitis B in women with substance use disorder. This study design is cluster randomized controlled intervention trial without blinding and randomization are in the centers to five intervention and five control centers. The study population are 100 women with substance use disorder referring to Drop-in Centers, Harm reduction centers and camps who are over 18 years old, When filling out the questionnaire and participate in the class have the ability to answer and dialogue, Having at least degree of knowledge, substance use at least for 3 months, sexually active and lack of HIV infection. In this study intervention will be based on peer education by someone whit a history of substance use and provide information, including interpersonal skills, decision making skills and self-esteem, problem solving, the definition of hepatitis B and HIV and transmission of, techniques for the prevention of HIV, hepatitis b, dialogue and assertiveness techniques with the partner. Primary outcome are self-esteem, perceived vulnerability and performance toward HIV and hepatitis B that measuring with Rosenberg Self-Esteem questionnaire, Demographic, Sexual function questionnaire and Vulnerability to HIV and hepatitis B. Information will collecting before, immediately, one months and three months after the intervention.