Investigating the short-term effects of apple vinegar consumption on systolic and diastolic blood pressure, pulse pressure and heart rate in healthy subjects

Determination the short-term effects of apple vinegar consumption on the systolic and diastolic blood pressure, heart rate and pulse pressure in healthy subjects

A clinical trial with a control group will be used and randomization will be done on the basis of random blocks.

Volunteers are selected based on the criteria for entering the study. On the day of the test, 4 hours after breakfast, the control group receives 200 cc of water while the test groups receive specific doses of 5% vinegar (22, 28 and 34 g vinegar), which are raised to 200 cc by adding water. Blood pressure is measured by a pressure indicator and heart rate on the basis of the electrocardiogram before receiving vinegar and with 15-minute intervals after receiving vinegar for 120 minutes using the same method. This study will be conducted at the cardiovascular Research Center of Guilan University of Medical Sciences.

Inclusion criteria of study are: Healthy people with no history of allergy to vinegar, no smoking, having a body mass index between 18.5 to 29.9 Kg/m2. Exclusion criterion of study is: unwillingness of individuals to cooperate with the study procedure.

The control group will receive single dose of 200 cc of mineral water. The intervention group 1 will receive single dose of 22 grams of 5% traditional apple vinegar whose volume is raised to 200 cc by adding water, the intervention group 2 will receive single dose of 28 grams of 5% traditional apple vinegar whose volume is raised to 200 cc by adding water, the intervention group 3 will receive single dose of 32 grams of 5% traditional apple vinegar whose volume is raised to 200 cc by adding water.

Reduction of systolic and diastolic blood pressure

Randomization method and description: Randomization method is based on gradual referrals and having inclusion criteria and interest in participating in the study. Randomization unit: individual Randomization layers: gender Randomization Tool: Random Allocation Software The method of creating a random sequence: Sequence Allocation concealment: Selection sequence of samples is divided into four groups of women (20) and men (20) that are kept in sealed letters at the Cardiovascular Diseases Research Center of Heshmat Hospital at Rasht and are opened at the beginning of the study each morning and closed at night from outset of the study. Based on the sex of the samples and having the criteria for entering the sequencing, the samples are placed in one of the four groups (low dose - moderate dose- high dose and control).