Comparing the effect of intravenous neostigmine and metoclopramide on gastric residual volume of mechanically ventilated intensive care unit patients

Comparing the effect of intravenous neostigmine and metoclopramide on gastric residual volume of mechanically ventilated intensive care unit patients

This assessment is a clinical trial in phase 3, patients with inclusion criteria for study, are considered as study group. In this study, 100 patients are selected. Patients are categorized based on non randomization method, 50 patients in the neostigmine group and 50 patients in the metoclopramide group. Accordingly, before starting the drug infusion and 3, 6, 9 and 12 hours after the start of the infusion, the gastric residual volume is evaluated by aspirate with a gavage syringe.

This study was carried out as a clinical trial at the Khatam Al Anbia Hospital in Zahedan, Also the study will also be single blinded in which patients will be blinded in study.

Inclusion criteria included as age between 20 and 50 years, patients under mechanical ventilation and patients with enteral nutrition through nasogastric tube. Also exclusion criteria included as previous use of beta blockers, heart block, bradycardia (heart rate less than 60) before inclusion, hypothermia in the form of central temperature below 35 degrees, kidney Failure (CR> 1.5), use erythromycin or cisapride within 8 hours before starting the study, recent surgery on stomach or digestive tract within the last ten days, signs and symptoms of bowel obstruction, pregnancy and lactation, active bronchospasm, extrapyramidal symptoms, sensitivity to neostigmine and active gastrointestinal bleeding.

In the first group, neostigmine was used at 2.5 mg / 100 ml of normal saline and In the second group used metoclopramide at a dose of 10 mg / 100 ml of normal saline.

gastric residual volume

This means that patients in groups do not know the used drugs, and drugs has similar packaging.