This is a Single-blind randomized controlled clinical trial will be done in Imam Reza hospital in Kermanshah Iran. Inclusion criteria: all women undergoing abdominal hysterectomy for benign gynecologic disease and Exclusion criteria include patients who have contraindications to misoprostol, including mitral stenosis, heart disease, glaucoma, sickle cell anemia, severe hypertension, diastolic blood pressure above 100 mm / hg, severe asthma, or known hypersensitivity to prostaglandins, known endometriosis patients with a history of pelvic or active disease, diabetes, obesity (BMI> 30), a history of previous myomectomy and previous use of GnRH agonists before surgery, patients with invasive cancer endometrial, cervical and ovarian tumors.
It is estimated sample size of 60 patients in the study group (1) 2 tablets of 200 mcg misoprostol an hour before practice and in the control group (placebo) pill vitamin B6 two an hour before the operation placed under the tongue. The primary outcome measure of intra operative blood lost include blood collection obtained by bottles suction and the weight difference between wet and dry gauze. Length of surgery from incision to skin closure, Hb level before and 24 hour after surgery, need to transfusion, length of hospital stay and fever ask secondary outcome measure will be recorded.