Comparing the effects of Furosemide, Mannitol, and Dopamine on Diuresis in Patients with Cesarean Section under Spinal Anesthesia

Comparing the effects of furosemide, mannitol, and dopamine on diuresis in patients with cesarean section under spinal anesthesia.

Patients are randomly divided into three intervention and one control groups and the study is design as a randomised, controlled, parallel group trial with double blinded outcome assessment. Randomisation will centralised based on simple randomization method using random digits table.

Eighty patients undergoing cesarean section are randomly divided and evaluated into three intervention and control groups (n=20) in Ahvaz Imam Khomeini hospital. Participants, researchers responsible for data collection and analyses are blinded to the groups allocation.

Inclusion criteria are patients in age group 18 to 45 years and complete pregnancy period (based on weeks). The exclusion criteria are patients with acute renal failure with inadequate cardiac output and tissue perfusion, dialysis-dependent patients and not having normal levels of creatinine and BUN.

Mannitol group received 100 ml 20% mannitol serum intravenously for the last 30 min of the surgery; furosemide group received infusion of 0.25 mg/kg of furosemide in 500 cc normal saline serum for 30 min of the surgery, dopamine group received a renal dose of 0.25 to 2 μg/kg/min in 500 cc of normal saline serum, and control group received 500 cc normal saline serum without any drug for 30 min.

The urine output is measured at 0 (immediately after admission to recovery room), 2 and 6 hours after the completion of the surgical operation.

Individuals are randomly divided into four groups based on simple randomization method using random digits table. In this method, a collection of non-template numbers is randomly generated and arranged as a table. A collection of numbers is considered for each group and the patients are asked to select one of the table numbers. According to the selected number, they are randomly assigned to one of the intervention or control groups.

Participants are informed about the purpose and method of study. After receiving informed consent, they are blinded to the study groups to unify patients in terms of their empathy sense. Researchers responsible for data collection and analyses will also blinded to the groups allocation for preventing personal viewpoint.