Comparison the effect of preoperative oral clonidine and placebo on shoulder pain in laparoscopic cholecystectomy with general anesthesia

The purpose of this study will be to assess the effect of preoperative oral clonidine and placebo on shoulder pain in elective laparoscopic cholecystectomy with general anesthesia

Clinical trial with two arm parallel groups, randomised trial with double blinded assessment. Study phase will be 2-3.

In Urmia Imam Khomeini hospital operating room the patients with elective laparoscopic cholecystectomy with general anesthesia will be devided into two parallel groups (32patients per group).The drug will be administered by the nurse in the ward and at the time of admission, the anesthesiologist will be unaware which patient will be assigned to which group. Drug containers will be identical and only the nurse will know about the contents of each of them, and finally, after collecting information by the resident in training in anesthesiology, the anesthesiology specialist will be informed of the group each patient is assigned to. After surgery shoulder pain will be compared with each other.

Inclusion criteria:Being at the age of 20 to 60 years old, American Society of Anesthesiologists class I and II, Elective laparoscopic cholecystectomy surgery Exclusion criteria: Hypertension, Heart disease, Gastritis, kidney disease, Lung disease, Mental disease, Addicted to all kinds of opioid drugs, People treated with, beta-blockers, People treated with methyl dopa, Individuals treated with monoamine oxidase inhibitors, use of analgesic drugs, Body mass index above 25 kg / m 2

Intervention group: patients will receive clonidine 150 Microgram oral tablet, 90 minutes before surgery. Control group: will be received oral placebo 90 minutes before surgery.

pain

Patients will be randomly assigned into two groups of clonidine 150 Micrograms (group C) and placebo (group P) using Random Allocation Software 2.0, and the target codes will be written on a piece of paper and placed in sealed envelopes with sequential allocation.

The drug will be administered by the nurse in the ward and at the time of admission, the anesthesiologist will be unaware which patient will be assigned to which group. Drug containers will be identical and only the nurse will know about the contents of each of them, and finally, after collecting information by the resident in training in anesthesiology, the anesthesiology specialist will be informed of the group each patient is assigned to.