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Study aim
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Beneficial and therapeutic effects of silymarin and N-acetylcysteine(NAC) antioxidants on hepatic and renal impairment and hypertension in preeclampsia patients.
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Design
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Clinical trial without control group,with two parallel groups, two blind strains, randomized in a simple way
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Settings and conduct
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The medicines Provides the resident with the same packaging and coding before the study begins.One contains 70 mg of silymarin and the other contains 600 mg of NAC.In the maternity ward of Hajar hospital in Shahrekord, patient data and previous tests including blood pressure, liver tests and platelet count are extracted and recorded in relevant lists..Both patients receive routine preeclampsia treatment including magnesium sulfate and hydralazine.Medications in both intervention groups were administered orally and immediately and 12 and 24 hours after termination of pregnancy. AST, ALT, ALP.Billirubin total, direct,BUN, Cr and proteinuria and platelet counts were repeated 12, 36, and 60 hours after drug administration, respectively.At the end, the variables of the two groups are compared.
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Participants/Inclusion and exclusion criteria
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Conditions of entry of mothers between the ages of twenty and thirty with body mass index between twenty to twenty-four and gestational age of thirty-five to forty-two weeks with no history of abortion and pregnancy and blood pressure greater than 140/90 mmHg before termination of pregnancy and positive urine protein before termination of pregnancy.Exclusion criteria: history of hypertension and diabetes, renal disease, collagen and vascular diseases and cardiovascular disease, history of smoking, alcohol and maternal dissatisfaction
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Intervention groups
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One group received silymarin and the other group received NAC
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Main outcome variables
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serum liver enzymes; plt count;urea;creatinine; proteinuria;blood pressure