Comparison of Dexmedetomidine and Fentanyl as Adjuvant to intrathecal Ropivacaine in Lower Limb Orthopedic Procedures

Comparison of the effect of adding dexmedetomidine or fentanyl to intrathecal ropivacaine on sensory and motor characteristics and analgesia after orthopedic lower limb surgery

90 patients undergoing lower limb orthopedic surgery are divided into three groups by block randomization method. Patients in the three groups were injected with 4.5 ml of ropivacaine with 5 mg dexmedetomidine in 5 ml normal salin, 4.5 ml ropivacaine + 25 mg fentanyl in 5 ml normal salin and 4.5 ml ropivacaine 5%, respectively. Isobarics were administered in 5 cc normal salin every 15 minutes. Hemodynamic parameters, postoperative pain intensity every 15 minutes, and time to sensory and motor block arrival were also determined in three groups.

This study was performed on patients undergoing lower extremity orthopedic surgery at Alzahra Hospital, Isfahan, Iran. This study is a double blind study.

Inclusion criteria include: Weight less than 100 kg and Candidate Orthopedic Lower Limb Surgery and patient consent to participate in the study. Exclusion criteria included: Chronic pain report lasting more than 6 months, drug or ropivacaine sensitivity, fentanyl and dexmedetomidine, prohibition of spinal anesthesia, history of long-term drug use, or NSAIDs, or disease It is chronic.

In the first group: 4.5 ml ropivacaine 3% isobaric + 5 mg dexmedetomidine is injected in 0.5 cc normal salin. In the second group: 4.5 mlRopivacaine 3% isobaric + 25 mg fentanyl is injected in 0.5 ml normal salin. In the third group: 4.5 ml ropivacaine 5% isobaric intrathecal is injected in 0.5 ml of normal salin.

Time to reach sensory block, Time to motor block, Maximum level of sensory block, Blood pressure, Heart rate, Oxygen saturation, Postoperative pain

In this study, 90 patients undergoing lower limb orthopedic surgery were randomly divided into three groups of 30 each. Random allocation of patients between the three groups is done using random allocation software. At first the total sample size is entered into the software and then the number of study groups is entered. In software output, numbers 1 to 90 are randomly presented in three separate columns, according to which patients are divided into three groups according to the time of inclusion and as listed above to reach the required number in each group

The study was conducted in a double-blind manner and patients and researchers were uninformed with the type of drug administered. The drugs are drawn and coded on a similar syringe by an operating room staff member who is not involved in the study and provided to the plan administrator for injection.

The plan is owned by the government agency and cannot be shared.