Comparison of the effectiveness of intravenous paracetamol before surgery on the dose of opioid during and after radical prostatectomy.

Comparison of the effectiveness of intravenous paracetamol before surgery on the dose of opioid during and after radical prostatectomy.

This study is a double-blind randomized clinical trial in which the number of patients is determined according to the sample size formula and using a simple randomization method, which uses a random number table for each patient. The code is given and patients are randomly assigned to two treatment groups, with random code selection.The number of samples in this study is 36 patients.

First, the intensity of preoperative pain in all patients will be determined before surgery, based on the visual analogue scale system. All patients undergo general anesthesia.Then, one hour before the surgery, in the first group, an intravenous paracetamol will be injected at a rate of one gram and then they will receive one gram an hour after the anesthesia injection and the second group will receive the same amount of placebos. During surgery, the dose of Injectable Opioid that includes Opioid administration every hour during surgery (Fentanyl based on the patient's weight) as well as the required postoperative Opioid based on the VAS required for the patient will be determined and recorded in two groups. Also, the severity of pain after surgery will be determined and recorded at recovery times, 2, 8, and 24 hours after recovery.

Inclusion criteria: Age over 40 years Exclusion criteria: History of chronic drug use, Liver disorder, Kidney disorder

Group 1: One hour before surgery, they will receive one gram of intravenous paracetamol and one gram after anesthesia. Group 2: One hour before surgery, placebo will be given one gram and one gram after anesthesia.

Severity of pain, dose of opioids, length of hospital stay

In this study, we use the block randomization method to create equal groups. To randomize the two treatment methods, we create 4 blocks in six different states, then select a number using the table of numbers, and determine the study groups by matching the numbers with the blocks. 1. TTCC 2. TCTC 3. TCCT 4. CCTT 5. CTCT 6. CTTC For example, if the first digit of our number is 1 to 6, select a block and the division is done, but if, for example, our number is 94071, the digit 9 is not valid and we select the next digit. Here, based on the block, we divide 4 people into groups.

The researcher and the person analyzing the study information are unaware of the study groups and are identified as groups A and B.