Correlation between high dose of vitamin D3 and rise of hemoglobin in mechanical ventilation patients in medical ICU

Evaluation of correlation between high dose vitamin D3 prescription and rise of hemoglobin

A clinical trial with two groups of intravenous Vitamin D and control, with parallel groups, randomized based on simple randomization with https://www.randomizer.org site,double-blind phase 3 with 50patients in each group (totally 100)

in this double-blind randomized clinical trial nurse will give the patient vitamin A3 or placebo. For this purpose, during 6 months in Imam Hossein Hospital, ICU Medical ward, all patients admitted who have the conditions to enter the study and are under mechanical ventilation are randomly divided into two groups. After recording the demographic information, including age, sex, and underlying diseases, the objectives of the study will be explained to the patient and they will enter the study if they wish and obtain written consent. First, the concentration of hemoglobin and the level of vitamin D3 are checked. Then, in a placebo group and in a group of vitamin D3 with 50,000 units, we gavage for 5 days. We record the patient's hemoglobin level one week later. Hemoglobin will be measured and recorded once a week for a maximum of one month.

100 patients over 18 years of age, under mechanical ventilation, admitted to the internal ICU, who are hospitalized in the ICU for 6 months and undergo mechanical ventilation, will be randomly assigned to the two treatment groups with vitamin D and placebo. Patients with chronic liver and kidney disease anemia and patients discharged from the ECU 12 days ago are excluded from the study.

Intervention group (Vitamin D): Nurse for this group Vitamin D3 with 50,000 units for 5 days of gavage Control group: The ward nurse injects a placebo for the opposite group

Measure and record hemoglobin

Randomization method: Simple randomization -Randomization unit: individual -Randomization tool: Randomization will be done using the site https://www.randomizer.org which using random numbers extracted by the software, patients will be given one of the two groups of Vitamin D and control. Input software: number of sets (in our study a set of 100) Number of samples in each set (100 samples in total) The range of data in each set (in our study from 1 to 2, ie 1 group therapy and 2 placebo groups, separation from 50 to 1 50 to 2) Output software: one set of 100 numbers from 1 to 2 that are placed in the treatment group or placebo at the time of infection using these 1 and 2 drug codes.

Drugs for both groups will be prepared and coded by one of the researchers in the study. Participants in the study who enter the study after obtaining informed consent. In this study, the first group of patients was given oral vitamin D and the second group was given a placebo. The patients' blood samples were taken and their hemoglobin was checked by ICU doctors, who did not know which vitamin D disease or which placebo they were taking.