Evaluation of the effect of oral pentoxifylline on prevention of radiocontrast nephropathy in patient that undergone angiographye

A comparison of the effect of pentoxifylline on the prevention ofradio contrast nephropathy in patients with renal dysfunction and patients with normal renal function

Patients are divided into two groups: normal kidney function and renal dysfunction, and each group is randomly divided into two groups to receive saline or saline with pentoxifylline (400 mg orally three times a day). Clinical trial with control group, with parallel groups, double-blind, randomized, phase 3 on 190 patients. Use the rand function of Excel software to randomize Sampling will be continuous. The statistical method used is SPSS software

Each group of patients will be divided into two groups of normal saline 1cc / kg / h and normal saline and pentoxifylline (400 mg orally three times a day). Patients' creatinine will be tested the day before angiography the next day and 48 hours later, and at the end the two groups will be compared and the CKD patients in the groups will be compared.Patients, statistical analyzers,and researchers will be blind.

Criteria for entering the study of all patients who need to perform vascular angiography in terms of cardiac service. Criteria for exclusion of the study are patients with stage 5 CKD , kidney transplantation, patients with renal insufficiency with a GFR below 30, and patients with a history of allergy to pentoxifylline according to history.

Get normal saline serum with pentoxifylline (400 mg orally three times a day for 24 hours before angiography(1st group), get normal saline foe 2nd group

Creatinine and it"s clearance are the main variables. Other variables are urinary output, protein excretion, CRP, urine examination.

This division is based on a table of random numbers.The method of randomization is simple.According to the table of numbers, patients are divided into two groups: case and control.. Patients who visit on even days will be in the target group and patients who are admitted on odd days will be in the control group

In this study, participants and who evaluated the results and analyzer of the data were blind.Patients who are candidates for angiography are coded according to the schedule.The person encoding is blind about the target and control group .The patient then enters the group based on the received code. Data collection and analysis is done by someone who has no knowledge of the details.