Comparative study of the effect of hydralazine and nifedipine on acute hypertension in women with preeclampsia

The aim of this study was to compare the effect of hydralazine and nifedipine on the reduction of acute hypertension in women with preeclampsia in Asali Hospital in Khorramabad.

Clinical trial with control group, one-way blind, randomized, 60 patients in two groups of 30 people,Simple randomization was used

60 pregnant women with preeclampsia with a blood pressure of 160 on 110 mm Hg and above, who meet the inclusion criteria after obtaining informed consent will be randomly assigned to the study groups, and in one of two injection groups Hydralazine or oral nifedipine will be administered. Accordingly, in the injection group of hydrolazine, 5 mg of the drug will be injected intravenously and an oral drug that does not contain drug content will be used for blinding. In the nifedipine group, 10 mg tablets up to a maximum of four doses are used if needed, and normal saline intravenous injection is used for blindness.

In this study, inclusion criteria include pregnant women 18 to 45 years, gestational age greater than or equal to 20 weeks, blood pressure greater than or equal to 160 over 110, and exclusion criteria include maternal heart disease (cardiac arrhythmia , heart failure , chest pain, etc.), kidney, liver disease and fetal disorders, including intrauterine growth restriction, oligohydramnios, and uncertain patterns of fetal heart rate.

The intervention groups will consist of two groups of 30 people with a total of 60 people. In the intervention group number one, to reduce blood pressure, 5 mg of hydralazine will be used intravenously every 20 minutes, and in the intervention group number two, To reduce blood pressure, nifedipine 10 mg orally will be used every 20 minutes.

Primary outcome variables include systolic blood pressure and diastolic blood pressure.

Randomization will be assigned to the study groups in a simple, even and odd manner. The randomization tool will be the use of a random number table in such a way that people in the group of even numbers are characteristic of group one, ie hydralazine, and people with odd numbers in the group. 2 nifedipine will be placed

In the group receiving nifedipine, four doses of the drug will be given to the patient according to the instructions and intravenous injection of distilled water will be used to blind the patient. In contrast, in the group receiving hydralazine, the main drug will be injected intravenously at a dose of 5 mg. People in this group will use the placebo in pill form

It is possible to share all the data while maintaining the principle of not mentioning the names of individuals

One year after the publication of the related article

Researchers of university centers

The data of the present study can be used after obtaining permission and approval from the Vice Chancellor for Research and Technology of Lorestan University of Medical Sciences

Refer to the project manager, Dr. Fatemeh Yari, with email address yari1672@yahoo.com, and contact number 09163613621

After completing the research and publishing the relevant article, individuals can apply to the Vice Chancellor for Research and Technology of Lorestan University of Medical Sciences to receive documents and after obtaining permission from this department, send a confirmation from the Vice Chancellor for Research to the project manager. Can access documentation.