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Study aim
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Evaluation of oral and vaginal tabletsisosorbide mononitrate and oral propranolol tablets for Preinduction of Cervical Ripening in primiparous term pregnancy
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Design
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Clinical trial with control group, one-blind, randomized, phase three on 120 patients. Excel software rand function was used for randomization
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Settings and conduct
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In a randomized single-blind randomized clinical trial 120 pregnant women of normal term with normal pregnancy and with a score of 2 or less who were referred to Yas Hospital in Tehran were selectedand were randomly divided into four groups by random allocation.The intervention groups did not know the type of drug.
Intervention groups included a group of vaginal isosorbide mononitrate( 40 mg), one group of oral isosorbide mononitrate( 40 mg), one group of oral propranolol tablets(20 mg), and one control group without The
intervention .Cervical maturation was measured before and 24 hours after the intervention.
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Participants/Inclusion and exclusion criteria
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Inclusion criteria: 37-40 weeks gestation،primiparous, live fetus,single fetus, cephalic, intact membranes ,Bishab score under two, fetal weight less than 4 kg.
Exclusion criteria: History of headache, alcohol , preeclampsia ,IUGR, polyhydramnios and oligohydramnius, placenta previa
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Intervention groups
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Intervention groups included a group of vaginal isosorbide mononitrate (40 mg), one group of oral isosorbide mononitrate ( 40 mg) , one group of oral propranolol tablets ( 20 mg) and one control group without The intervention 30 people was measured.
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Main outcome variables
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Method of delivery, time elapsed to dilation 6cm Duration elapsed time from dilatation 6 cm to full dilation, Time elapsed from full dilation to delivery, Maternal complications, Bishop score change 24 hours after receiving the drug, Apgar 5 min, Cord pH, NICU hospitalization, meconium excretion, need for oxytocin to induce labor