The effect of Goal-directed fluid therapy on intraoperative transfusion rate in spine surgery in Golestan Hospital in 1399

The aim of this study was the effect of targeted fluid therapy on the rate of intraoperative transfusion in spine surgeries in Golestan Hospital in 1399.

60 patients will be included in the study and will be divided into two groups of control and case (30 patients in each group) as simple parallel and randomized groups.researchers or analysts of the collected data will be blinded.

This double-blind clinical trial study is performed in Golestan Hospital, Ahvaz. Fluid therapy of patients in the case group will be based on hemodynamic parameters (changes in stroke volume) and in the control group, fluid therapy will be performed according to the standard protocol. researchers or analyzers of the collected data will not be informed of which group the patients belong to.

Inclusion criteria include: age 18 to 70 years, candidate for spine surgery, absence of heart, kidney and liver disease, no use of anticoagulants. Exclusion criteria include: patient dissatisfaction, the Existence of pulmonary ral and crackle and pleural effusion

For patients in the intervention group, targeted fluid therapy will be performed according to the protocol. Before induction, 4 mg/kg of crystalloid solution (Ringer) is given and then the hemodynamic invasive monitoring device will be installed through the radial artery, which is given crystalloid based on the variance of the impact volume of the therapeutic fluid. Patients in the control group will undergo conventional fluid therapy using the 1-2-2 mg / kg / h rule at a rate of 10 ml/kg/hr crystalloid (normal saline/Ringer serum).

Number of blood units required, bleeding rate, acidosis incidence, urinary output, vasopressor requirement, postoperative ventilator requirement and intraoperative crystalloid requirement

Patients who are candidates for spinal surgery will be selected by census according to the inclusion criteria and will be treated randomly using envelopes containing a code A (Targeted fluid therapy group) and B (Routine fluid therapy group).

Due to the double-blindness of the study, patients did not know whether they were in the routine or targeted fluid therapy group, and the recorder was unaware of whether the patients were in the study group or controls, and the statistical analyzer was unaware of the grouping and injection solution.