Effect of vitamin D on serum level of Insulin-like growth factor 1 in 5-10 years old children with idiopathic short stature

The effect of vitamin D supplementation on IGF-1 levels in children with idiopathic short stracture

In the present study, 60 children aged 50 to 10 years with short stature, 30 of whom had vitamin D levels less than 30 ng / dl and the second 30 had normal vitamin D levels, were selected and the first group was treated with vitamin D. In the second group, no intervention is performed. Insulin-like growth factor levels are determined and compared at the beginning and end of the intervention in the two groups.

Isfahan Imam Hossein Hospital, children with vitamin D levels less than 29 ng / ml, were treated with 50,000 units of vitamin D supplement per week for 8 weeks. After 3 months of treatment, vitamin D and IGF-1 levels were measured again and the results were recorded along with other patient information in the data collection form.

Inclusion criteria included: idiopathic short stracture, age range 5-10 years, low IGF-1 level, vitamin D level less than 29 ng / ml and parental consent to participate in the study.

Children with vitamin D levels below 29 ng / ml are treated with 50,000 units of vitamin D supplement per week for 8 weeks. Vitamin D is not recommended for children with vitamin D levels above 30 ng / dL. Vitamin D levels and insulin-like growth factor are measured and compared in two groups at the beginning and end of the study.

The present study showed that with the elimination of vitamin D deficiency, the level of IGF-1 increases, so it seems that in children with idiopathic short stracture, eliminating vitamin D deficiency can be effective in eliminating IGF-1 deficiency.

Randomization of patients in both groups is done using random allocation software. In the mentioned software, the total number of sample size and the number of groups are entered and the software output includes a list that has randomly distributed the total sample size in two groups according to the number. Patients are distributed in two groups according to the time of referral according to the list.

After obtaining permission from the University Medical Ethics Committee, the researcher referred to the endocrinology clinic of Imam Hossein Hospital, found children with inclusion criteria, explained the objectives of the research to the patients' parents, and after obtaining written consent, 5 ml of blood sample. Intravenously will be taken from children to measure 25-hydroxy vitamin D and IGF-1 levels

The plan belongs to a government agency and cannot be shared.