Inclusion criteria:
Iranian nationality
Married
Older and equal to 18 years
Gestational age 12 to 20 weeks
Having a single fetus according to ultrasound confirmation
Initial bishop score less than four
BMI less than 30
Indication of termination of pregnancy due to intrauterine death of the fetus with confirmation two ultrasounds
Exclusion criteria:
Drugs abuse
smoking more than ten cigarettes a day
History of cesarean section
Contraindications to the use of evening primrose include: history of mental illness with phenothiazine, history of epilepsy, schizophrenia, history of bleeding disorders and use of anticoagulants
Medical disorders in the mother such as heart disease, lung disease, active liver disease, acute hepatitis
Previously known drug allergies to misoprostol include drowsiness, tremors, seizures, shortness of breath, hypotension, and bradycardia (WWW.Drugs.com)
Medicinal allergies to evening primrose, including urticaria, wheezing, facial edema, lips, tongue and throat (WWW.Drugs.com)
Severe anemia
Having cervical anomalies
Evening capsule vaginal capsule for two weeks continuous
Severe vaginal bleeding
Enema
Having a history of unsuccessful pregnancy
History of using any herbal and chemical drugs to help abortion before admission
Contraindications to misoprostol use include: ectopic pregnancy, use of estrodiol-free drugs, symptoms of pelvic infection or sepsis, unstable hemodynamic status, mitral stenosis, glaucoma, asthma, bronchitis