Comparison of the effect of intravenous Esmolol and intravenous Lidocaine on hemodynamic variables during laryngoscopy and tracheal intubation and postoperative nausea and vomiting in patients undergoing abdominal surgery

Comparison of the effect of intravenous Esmolol administration with intravenous lidocaine on hemodynamic variables during laryngoscopy and endotracheal intubation and postoperative nausea and vomiting in female patients undergoing abdominal surgery

This study is a one-blind randomized clinical trial, without control group, with 2 intervention parallel groups and phase 2-3, in which 64 patients are randomly divided into 2 groups of 32 using a random number table.

This trial is performed by a researcher in the Kowsar operating room of Shahid Sadoughi Hospital in Yazd, in 2 groups of 32 people. Patients do not know the type of drug, In the first group, Labetalol and the second group, lidocaine is injected intravenously. The mentioned hemodynamic variables are measured in the times; immediately before the injection of drug and laryngoscopy, immediately after endotracheal intubation, immediately after skin incision and the result is recorded in the questionnaire. side effects; Bradycardia, hypotension, nausea and vomiting are evaluated and recorded in a questionnaire. Finally, the results are analyzed by SPSS software and relevant statistical tests

Inclusion criteria: All female patients who are candidates for gynecological abdominal surgery Exclusion criteria: arterial hypertension, ischemic heart disease, severe heart disease, ASA Class I, II, pulmonary, renal, hepatic, addiction.

A total of 64 patients are randomly divided into two groups of 32 using a random number table. In the first group, intravenous osmolol (0.5 mg / kg) is injected immediately before induction of general anesthesia and in the second group, intravenous lidocaine (1.5 mg / kg) is injected.

Hemodynamic variables including systolic, diastolic, mean arterial blood pressure and heart rate

In order to randomly allocate 64 eligible applicants, we randomly divide them into two groups of 32 people. For this purpose, we use Random allocation software version 1.0 under Windows to creat sequence, and by using this software we make A list which is specified from 1 to 64 with group A or B treatment By using this list, we give the first oerson who is eligible to enter the study, number 1 and the last person the number 64, then based on the random allocation list and by the software, it is determinded which group A or B each person is in.

Only patients are unaware of how to group and the amount and type of medication used It is necessary to mention in this research the drugs used and Their levels in both experimental groups are completely routine and tested The only side effects of the drug from the time of injection of the drug until the end of its effect and Nausea and vomiting are assessed in two groups and recorded if they occur.