Objectives: Conjugated linoleic acid (CLA) has anti-inflammatory, antioxidant, anticancer, anti-atherosclerosis, immune system improvement properties, and change of lipid metabolism. Therefore, it can play an important role in decrease of inflammation and increases body's antioxidant defenses. The aim of this study is investigation of consumption effect of CLA supplementation on oxidative stress and matrix metaloproteinases (MMPs) in young healthy men.
Design: 30 healthy males with moderate physical activity will be selected into two groups (15 controls and 15 tests) at 18-30 years old. About 5.6 g CLA and 5.6 g oral paraffin supplementation will be given to test and control groups for 14 days, respectively. Exhaustive exercise session will be given to both groups at the end of 15th day.
Setting and Conduct: Fasting blood samples will be taken for measurement of biochemical factors for both groups at the starting, before and after exhaustive exercise.
Participants including major eligibility criteria: Young healthy males with moderate physical activity in 18-30 years old.
Participants including major eligibility criteria: Individuals with certain diseases, smoking, alcoholism and other supplements, having certain dietary, professional training, sedentary and having 25<BMI<18.5 (body mass index) Kg/m2;
Intervention: Conjugated linoleic acid (CLA) will be used for intervention.
Variables: Superoxide dismutase, Glutathione peroxidase, Malondialdehyde, Interlukine-6, Tumor necrosis factor-alpha, Matrix metalloproteinase-2, Matrix metalloproteinase-9, High- sensitive C-reactive protein and other parameters.