Comparative study of the preemptive Dexmedetomidine with Ondansetron effect in reducing the post-operative nausea and vomiting after elective middle ear surgery under general anesthesia

If we find the most effective drug in reducing the post operative nausea and vomiting the patient satisfaction will increase and the expenditure of medical center will decrease.

Clinical trial with control group, with parallel group, three way blind, on 165 patient, random allocating software for randomization

The patients referring Alzahra and Ayatollah Kashani hospitals in Esfahan who are candidate for elective middle ear surgery, after obtaining informed consent are divided into three groups, under general anesthesia and intubation, receive drug according to their group, measuring of the severity of the nausea and vomiting in the recovery with visual analog scale (VAS).

Entry condition: the patient between the age 18 to 65 years old who consciously participate in study. Exit condition: liver or heart or kidney failure; death of patient; sensitivity to drugs in study; BMI more than 30.

After general anesthesia with fentanyl, lidocaine, thiopental and intubation and 15 to 20 minute before making a surgical incision, depending on which of the group O, P, D the patient belongs to receive drug or placebo. group O: 0/1 milligram per kilogram ondansetron; group D: dexmedetomidin 1 microgram per kilogram per minute; group p: 10 cc normal saline in 10 minutes.

Mean severity of post operative nausea; frequency of post operative vomiting; the average dose of antiemetic used; the average of first time; antiemetic needed; the first time that the fluid diet tolerated; the average time took to tolerate solid diet; mean patient satisfaction score; duration of anesthesia of patient; duration of surgery of patient; average length of stay in recovery; average of pain intensity; average time of extubation

165 people are selected by easy random method. The way to randomize is that anesthesiologist from a dark-colored bag containing 165 cards with titles O ( Ondansetron), D ( Dexmedetomidine), P ( placebo) that there are 55 of each card, and according to the card that is picked up the patient enters the investigation. (Output card will not be replaced).

Drug injections are performed by an anesthesiologist without knowing the contents of the syringes. (Also, all syringes have the same color and volume). The way to randomize is that anesthesiologist from a dark-colored bag containing 165 cards with titles O ( ondansetron), D ( dexmedetomidine), P ( placebo) that there are 55 of each card, and according to the card that is picked up The patient enters the investigation.(Output card will not be replaced). Patients also do not know about the medication they are receiving.