Aim and object: Preeclampsia and Eclampsia is the reason for 25% of maternal mortality and it is the most common cause for maternal mortality in developing countries against with infections and bleeding. Due to this reason, this study was performed as a randomized clinical trial for purpose of studying influence of Labetalol versus Hydralazine in control of severe preeclampsia and the outcome of pregnancy in Kashan city, 2010.
Materials and methods: The study was performed on 190 patients with severe Preeclampsia or Eclampsia confiding to control blood pressure, The women with past history of arrhythmia (even due to hyperthyroidism), twin or high risk pregnancy(non cephalic presentation, history of uterine rupture, or previous caesarian section, fetal anomaly, previous still birth, thick meconiom) were excluded. The patients with a hypertension record of more than 160/105 mmHg, were divided to 2 groups each containing 95 members they were entered in one of two groups: Hydralazine group (H) or Labetalol group (L). In (L) group, the patients received 20mg intra venous injection(Iv) every 20 minutes then 40 mg and then 80 mg every 20 minutes if blood pressure was not controlled, and in (H) group they received 5mg Hyralazine every20 minutes by Iv injection if blood pressure was not controlled and if blood pressure did not reduced successfully the dose would be repeated. Blood pressure in patients were measured in sitting position by mercurial pressure gauge with suitable cuff in two groups every time 15 minutes after injection, and it was performed by 1 st degree resident from their right arms. The outcome of pregnancy containing of, the pathway of delivery (the obligatory caesarian sections), the APGAR score of the neonate at 1 st and 5 th and the need of admission in the ward or NICU in all patients in Hydralazine and Labetalol groups were controlled by accomplished by accustomed midwife and pediatrician. The average total dose and the average time of prescription in both groups were controlled as well The data was analyzed by spss version 14 soft ware and chi-square ,T test, Levene test, MannU-Whitney tests.