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Study aim
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Determining the effect of Metoral in reducing the death of septic patients admitted to the intensive care unit.
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Design
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Septic patients over 18 years of age admitted to ICU wards by simple randomization with random number table divided into intervention and control groups, clinical trial, with parallel group, one-way blind, phase 2 on 36 patients.
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Settings and conduct
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Septic patients in ICU of Mousavi Hospital were simple randomly divided into 2 groups, the intervention group, receiving 25 mg metoral tablets every eight hours for 7days one-sided blind.others not receive metoral.Then lab indicators and the 14-day mortality of patients are determined
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Participants/Inclusion and exclusion criteria
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Inclusion criteria: Patients over 18 years of age admitted to the ICU wards of Ayatollah Mousavi Hospital in Zanjan with a diagnosis of sepsis that has not been diagnosed for more than forty-eight hours.
Inclusion criteria: Age under 18 years. Pregnancy. More than forty-eight hours have passed since the diagnosis of sepsis. Acute heart failure, AV block, bradycardia (heart rate below 70 beats per minute), heart shock, hypotension (systolic pressure below 90 mm Hg), pulmonary edema, patient sinus syndrome, ventricular dysfunction, acute bronchospasm, asthma, bronchitis Chronic Obstructive Pulmonary Disease (COPD), Emphysema, Pulmonary Disease, Peripheral Artery Disease, Raynaud's Phenomenon, Vasospastic Angina, Lactation, Pheochromocytoma, Myasthenia Gravis, Liver Disease
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Intervention groups
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Intervention group: septic patients in the intensive care unit, who were selected by simple randomization, receive 25 mg oral metoral tablets every eight hours for seven days with vital sign control.Control group:patients met the same criteria but did not receive metoral.
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Main outcome variables
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Blood pressure; Heart rate; Left ventricular ejection fraction; Sequential Organ Failure Assessment; 14 day mortality