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Study aim
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Determining and comparing the effect of topical spironolactone solution with topical clindamycin solution in the treatment of mild to moderate acne
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Design
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A clinical trial with a control group, 80 patients, phase 3, double-blind, randomized by Block Randomization method
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Settings and conduct
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This study is done in patients diagnosed with acne vulgaris who attend to dermatology clinic of Sina hospital.
Patients who met the inclusion criteria will be interviewed. All the patients' information such as age, sex, BMI, acne severity score, number and type of skin lesions (comedone, papule, pustule), and history of hormonal problems will be recorded in the checklist. patients will be divided into two treatment groups with the Block Randomization method. In order to avoid bias in this study, the researcher and the patient do not know the type of medicine assigned, and the study is conducted in a double-blind manner.
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Participants/Inclusion and exclusion criteria
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Inclusion Criteria :
People with mild to moderate acne, age 18 years and above
Exclusion Criteria :
Pregnant and lactating women, known sensitivity to clindamycin, history of using oral isotretinoin, laser or chemical peeling in the last 6 months, history of taking oral estrogen compounds in the last 3 months, history of using retinoid and antibiotics in the past one month, a history of using antimicrobial soaps and topical exfoliants in the past two weeks, chronic skin diseases such as psoriasis, lichen planus, vitiligo, weak immune system or taking immunosuppressive drugs
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Intervention groups
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Intervention group: treatment with 2% spironolactone topical solution made by an experienced pharmacist twice a day for 3 months
Control group: treatment with 2% clindamycin topical solution made by an experienced pharmacist twice a day for 3 months
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Main outcome variables
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Acne Severity