Comparative study of changes in heart rate and blood pressure in the use of Dosecam Ketamine with Dexmedetomidine and Dosecam Ketamine with Propofol in cataract surgery under local anesthesia by phacoemulsification method.

Investigating the effect of changes in heart rate and blood pressure in the use of Dosecam Ketamine with Dexmedetomidine and Dosecam Ketamine with Propofol in cataract surgery by phacoemulsification method

A randomized, controlled, double-blind, placebo-controlled clinical trial with a sample size of 128 patients was designed in a phase 3 trial.

This is a randomized double-blind clinical trial that will be conducted on 60 patients who are candidates for cataract surgery in Faiz Hospital, Isfahan. After the approval of the ethics committee of the university and obtaining the consent of the patients, the patients are randomly allocated into groups, in each group the desired intervention is applied and the patient's clinical symptoms are recorded. The person who applies the intervention is different from the researcher who evaluates the symptoms and also They do not know the type of intervention. Even though the patients are included in the study, they are not aware of the type of intervention applied and therefore they are all blind.

Patients aged 18 years and above r who undergo cataract surgery for the first time by phacoemulsification method and are in ASA class 1 to 3. Non-entry criteria: Patients with obstructive sleep apnea, diabetes, mental illnesses, autoimmune diseases, nystagmus, leukemia, epilepsy, patients treated with psychiatric drugs, deafness and drug allergy and use of painkillers in the past week, BMI index greater than 35 .

People who take the first combination of ketamine with dexmedetomidine in group a and people who take the second combination of medicine with dexmedetomidine and group b are placed in the group of the second combination of medicine and ketamine with propofol.

Heart rate ;blood pressure

Patients are collected by easy and continuous sampling method. . Then the samples were randomly divided into two groups by computer randomization using relevant software. Sampling continues until the samples reach the set limit. Sampling is done using unique codes and they are placed in 2 groups a or b. People who take the first combination of ketamine with dexmedetomidine in group a and people who take the second combination of medicine with dexmedetomidine and group b are placed in the group of the second combination of medicine and ketamine with propofol.

The method of blinding is that patients are unaware of the type of drug they are given and drugs provided in similar syringes and coded for those by the researcher and given to the study expert to inject. and the hemodynamic changes are monitored and recorded, so the attending, the clinical caregiver, the examiner, and the data analyzer will not understand the type of medication and the investigator deciphers the codes after data analysis.