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Study aim
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Comparision of corifollitropin alfa versus recombinant FSH in poor ovarian responders
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Design
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Clinical trial with a control group, with parallel groups, randomized, phase 3 on 90 patients. The rand function of Excel software was used for randomization.
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Settings and conduct
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This study is conducted as an RCT in 1401-1403 in the IVF department of Taleghani Hospital, Infertility Department. Patients with previous poor response in ivf cycles are assigned to two groups receiving corifollitropin alfa and recombinant FSH, which are assigned to one of the two treatment methods based on the randomization method with permutation blocks. will be divided
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Participants/Inclusion and exclusion criteria
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Inclusion criteria: patients with poor ovarian response in at least one previous ivf cycle, less than 40 years old, who had at least two of the following criteria: AFCL<5, AMH<1.2ng/dl, less than 3 oocytes in the previous cycle
Study exclusion criteria: uterine anomalies, history of untreated endocrine problems, heart, lung and liver problems and severe and uncontrolled underlying disease, unilateral or bilateral hydrosalpinx, prohibition of gonadotropin use, egg donors, severe male infertility (azoospermia, oligoasthenoteratospermia), stage 4 endometriosis, BMI <18 or >30
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Side panels
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Intervention groups
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patients with poor ovarian response in at least one previous ivf cycle, less than 40 years old, who had at least two of the following criteria: AFCL<5, AMH<1.2ng/dl, less than 3 oocytes in the previous cycle
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Main outcome variables
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the number of oocytes obtained, the number of embryoblasts and the number of blastocytes obtained, the fertilization rate, implantation rate, and pregnancy rate.