A comparison between the effects of midazolam, propofol, and dexmedethomidine on hemodynamics variation in patients undergoing cataract surgery under local anesthesia

Comparison of the effect of midazolam, propofol and dexmedetomidine for sedation of patients during cataract surgery under local anesthesia.

Clinical trial without control group, with parallel groups, double-blind, randomized, on 90 patients. A table of random numbers is used for randomization.

We use the double-blind method in which the patient and the researchers related to the study were not aware of the type of study group. anesthesia) is done in such a way that according to the three types of injectable drugs, three types of syringes are used, and only the anesthesiologist knows the type of contents of the syringes and the drugs received by the patients.

Inclusion criteria: Patients who are candidates for surgery, ASA class 2 and 3 patients, Patients in the age range of 18-90 years Exit criteria: The patient is pregnant, Occurrence of myocardial infarction in the last three months, History of reaction to benzodiazepine and dexmedetomidine drugs,

we will have three intervention groups of 30 people, in all three intervention groups, having a peripheral IV line with a diameter of 20 and fluid therapy (receiving 200-250 cc of normal saline serum) before and during the operation is the same for all patients. will be done. In all three intervention groups, before the preparation and drape of the patient, the target eye will be anesthetized with two drops of 0.5% tetracaine before the operation. Then, the intervention group will receive one midazolam drug, the intervention group will receive two propofol drugs, and the intervention group will receive three dexmedomidine drugs.

Hemodynamic changes including heart rate, systolic and diastolic blood pressure and arterial blood oxygen saturation level

In this study, a simple random allocation method will be used using a table of random numbers, so that in order to hide it, we used the double-blind method, so that neither the patient nor the researchers related to the patients were aware of the type of study group and the selection of the patient. His group and the type of medicine received will be done by one of the researchers not related to the patient (the person injecting the medicine who is an anesthesiologist).

In this study, we have used the double-blind method that the patient and the researchers related to the study were not aware of the type of study group, patient selection, patient grouping and the type of drug received by one of the researchers not related to the patient (injector drug, which is an anesthesiologist) was done in such a way that according to the three types of injectable drugs, three types of syringes were used, and only the anesthesiologist was aware of the type of contents of the syringes and the drugs received by the patients.