Comparing the effect of intravenous combined Paracetamol (Apotel) and Ketamine on postoperative nausea and vomiting in patients candidating hysterectomy

Comparison of the effects of ketamine and intravenous Epotel on reducing nausea and vomiting after hysterectomy surgeries.

A controlled, parallel-group, double-blind, randomized, phase 3 clinical trial on 114 patients. In this study, randomization will be done using the Sealed Envelope software and using the block method in blocks of 3 and 6.

The current study is a randomized clinical trial study that will be performed on 114 patients who are candidates for hysterectomy surgery (abdominal and laparoscopic). The environment of this project is Taleghani Hospital of Arak University of Medical Sciences. Since the study is designed in a double-blind manner, the patients will be randomly assigned to the receiving groups of ketamine, intravenous Apotel, and placebo, and the outcome assessors and clinical caregivers are not aware of the medication received.

Inclusion criteria: candidates for elective hysterectomy, general anesthesia, receiving opioids after surgery, age 25 to 65 years.Exclusion criteria: allergy to any of the drugs used in the study, history of mental illnesses

After induction of anesthesia in all participating patients, in the first intervention group, in the last 15 minutes of the operation, an amount of one gram of Aptotel is slowly injected intravenously. In the second intervention group, in the last 15 minutes of the operation, the amount of 0.15 mg/kg The drug is injected slowly and intravenously. In the control group, 30 cc of normal saline is injected.

nausea and vomiting

Patients will be assigned to two intervention groups and one control group based on the randomization sequence that will be generated in advance, in the order of arrival, and this sequence is unpredictable and its arrangement is completely random. To allocate the samples, the block randomization method will be used with the size of 3 and 6 blocks in such a way that by using the Sealed Envelope software to generate random numbers in the block method, the randomization sequence will be produced according to the required sample size for the three groups. In the beginning, all the modes in which 3 letters A, B and C can be arranged together in blocks of 3 and 6 are produced and randomly and by placing among the blocks, a block is selected and the pattern of arrangement in that block is for allocation. Patients will be used, then this block will be placed in the main container and another block will be selected again. 3 and 6 blocks will all be in one container.

This study is double blind. To observe the blinding of the first type, the patients do not know the type of medicine received. In all three groups, the same syringes are used, and the patient and the person in charge of the project do not know about their contents. In order to observe the blinding of the second type, the injection drugs were drawn in separate syringes by the respected anesthetist, and the person in charge of the project (a student) was drawn from the contents. It has no information.