Investigating the effect of vitamin C on the repair of extracted tooth socket

Determining the effect of vitamin C on the repair of an extracted tooth socket

A controlled, double-blind, randomized, phase 2 clinical trial on 54 patients. For randomization, random allocation version 1 software was used and for blinding, a placebo similar to vitamin C tablets in similar glass containers was used, where each batch is coded and only the researcher is aware of this coding process

This research is single-blind randomized clinical trial study. After examining the patients referred to Periodontology Department of Yazd School of Dentistry according to the entry and exit criteria and obtaining informed consent

Inclusion criteria: healthy patients aged 14 to 40 without medical conditions with noninfected bilateral symmetric premolars who require tooth extraction for orthodontic treatment, have no history of smoking or alcohol consumption, women are not pregnant or breastfeeding, patients have no psychiatric disease, and do not use corticosteroids or contraceptives containing estrogen. Exclusion criteria: patients who missed more than 1 dose of vitamin C

Tooth extraction will be done using a standard technique and under local anesthesia، each extracted wound site is measured 3 times, immediately after extraction, on day 7 and day 21 after extraction In the control group, gel foam impregnated with normal saline and placebo is used, in the systemic drug group, gel foam impregnated with normal saline and 750 mg vitamin C tablets are used, in the topical drug group, gel foam impregnated with 1% vitamin C solution and placebo is used In all 3 groups, the foam gel is inserted into the socket with a 4 zero vicryl suture in a figure eight shape to tighten the gel foam in the area

Socket depth; Mesiodistal dimension; Buccolingual dimension; Pharmaceutical group; Age; Sex

First, using the random allocation version 1 software under Windows, we generate a random sequence using a simple random allocation method. The result of the software is in the form of a software that specifies the numbers 1 to 54 along with the letters A, B and C, and the first qualified person will be assigned number 1, and the next people will get numbers 2 to 54. And the researcher places each qualified person in the specified group based on the random allocation table. In order to blind the random allocation, we ask the help of a third person who does not know about the interventions and the table is provided to him. When the eligible person comes, the intervention group that is with A, B and C groups will be asked by phone or SMS, and the person will be placed in the desired group.

For the purpose of blinding, the placebo is made in the form of round tablets with a yellow coating similar to vitamin C tablets of Amin Pharmaceutical Company and poured into similar glass containers, and each batch is coded. They don't know about received and done coding.

All data can be shared

From September 2021 to 1 year after the publication of the article

For all people, including those working in academic and scientific institutions and industry

Email and call

mohammad arab farashahi, 09133735190, sma.farashahi_69@yahoo.com

After sending the email, the data is transferred