Comparison of the effects of ginger, ondansetron and droperidol on nausea and vomiting after hysterectomy

Comparison of the effects of three drugs: ginger, ondansetron, and droperidol on nausea and vomiting after hysterectomy.

The clinical trial included three groups of ondansetron, droperidol, and ginger, and each group included 25 participants in parallel groups, double-blind, randomized, phase 2 on a total of 75 patients. All eligible patients will be randomly assigned to the three mentioned groups by the random block method.

patients in the ginger group, one hour before the operation, receive 4 ginger capsules, each containing 250 mg of ginger, and 4 ml of distilled water added to the serum to equalize the form of the received drugs. People in the ondansetron group receive 8 mg of ondansetron and 4 placebo capsules in the droperidol group, 2.5 mg of droperidol, and 4 placebo capsules. The preparation of the drugs is done by the researcher to blind the clinical caregiver of the patient. Then, in the period of 2, 4, and 6 hours after the operation, the patient's nausea will measure by the vas scale and the number of the patient's vomiting will record.

Entry criteria include no cancer, no high blood pressure, age between 18-60 years, ability to swallow the capsules used in the study, platelet count above 100,000, no intestinal obstruction and hepatitis, no use of anti-nausea and vomiting drugs or drugs that cause it, no long-term treatment with corticosteroid drugs, and no history of ginger allergy, not using blood thinners and anticoagulants before the operation, and the exclusion criterion is the patient's unwillingness to continue the study.

Ondansetron group, ginger group, droperidol group

Vomiting and the number of times the patient vomits are asked and recorded.

All patients with the entry criteria will be divided into three equal groups using a randomized block method; for each of the patients, the drugs studied in three groups were prepared by the anesthesiologist and they were prepared in the form of syringes of the same shape and color and with the same volume, and only 1-2-3 labels were placed on them. Then it will be given to the anesthetist technician of the project (who does not know the type of drugs) to be injected into the patients, also the patients do not know the type of drugs received. Additionally, the intern in charge of the project, who is responsible for completing the project questionnaires after the surgery, is also not aware of the type of study groups.

This is a double-blind study. Blinding of the participants was done using the same appearance of the drugs. Also, the patients did not have any information about which group they were assigned to. The blinding of the researcher was also done in such a way that one person delivered the medicine to a patient who did not know its type.

In order to protect the privacy and personal information of the patient, the non-disclosure of personal information and other such information is mentioned in the informed consent form to obtain the consent of the patient and her family.