Evaluation of the effect of non-surgical periodontal treatment on disease activity in patients with ankylosing spondylitis

Suggesting regular periodontal examinations and receiving SRP if the improvement of the condition of chronic periodontitis is effective on disease activity in patients with ankylosing spondylitis and periodontitis.

In this study, 2 control groups will receive oral hygiene instructions only, while 2 treatment groups will receive a non-surgical periodontal intervention including SRP. Periodontal indices will be done in 6 and 12 weeks after the intervention, and after 12 weeks, the BASDAI index will be measured to investigate the effect of non-surgical periodontal treatment on the inflammatory condition of ankylosing spondylitis on the control group.

This clinical trial study was conducted on 96 patients with active ankylosing spondylitis and moderate to severe generalized chronic periodontitis who were referred to a rheumatology center and were assigned to four groups (24 people in each group) using the random block method. be. which include two general case groups (periodontal treatment) and control (no periodontal treatment).

Inclusion criteria: age 18 years or older, confirmed diagnosis of active AS, moderate to severe diffuse chronic periodontitis, patients with at least 20 teeth.Exclusion criteria: taking antibiotics in a period of 3 months before the study, receiving non-surgical periodontal treatment in the last 6 months, smoking, severe liver or kidney failure, uncontrolled diabetes, heart disease, history of radiation therapy or chemotherapy, taking drugs with Possible effect on periodontium , severe dry mouth, pregnancy and breastfeeding patients who do not come to measure the investigated variables in the 6th and 12th weeks.

2 treatment groups will receive a non-surgical periodontal intervention including SRP.

Bath Ankylosing Spondylitis Disease Activity(BASDAI)

First, random blocks of eight containing four letters A, B, C, D (each letter is repeated twice) are generated, such as ABBDCACD. Then, among these 8 blocks, 12 blocks are randomly selected and a sequence of 96 is created, and each letter is placed in a sealed envelope, numbered from 1 to 96. These envelopes, which contain one of the letters A, B, C, D, are delivered by the rheumatologist to the qualified people. Only the generator of the random sequence of 96 knows about the contents of the envelopes. Patients go to the dental clinic with the envelopes and hand over the envelopes to the periodontist. People who have the letter A will be assigned to the first group and the letter B will be assigned to the second group and so on.