Determining the effect of 12 weeks of resistance training with different muscle tensions on mir-92, mir-204, mir-214, mir-233 and sclerostin in elderly women.
Design
The statistical sample of this research will be 45 healthy elderly women with an age range of 60 to 65 years living in Khorram Abad city. According to the initial estimate, 45 people will be randomly divided into three resistance groups 1 (15 people), resistance group 2 (15 people) and control (15 people). Then the experimental group will perform resistance exercises for 12 weeks and 3 sessions per week according to the protocol.
Settings and conduct
After obtaining the necessary permits from various authorities including the University of Medical Sciences and the ethics committee and coordinating with orthopedic specialists, then the research samples will be referred to the parks and the retirement organization, and the statistical sample of this research is 45 healthy elderly women with a range of 60 to 65 years old residents of Khorram Abad will form.
Participants/Inclusion and exclusion criteria
Participants must be residents of Khorram Abad city, be menopausal, not have any sports activities in the last six months
Intervention groups
The resistance training protocol in the first group is in the form of three periods of 12 repetitions with 75% of a maximum repetition and with two-minute rests between periods, with a duration of one second of muscle tension (one second of flexion and one second of extension) and in the second group in the form of three The three-repetition period was performed with 50% of a maximum repetition and with two-minute rests between periods, with a duration of six seconds of muscle tension (six seconds of flexion and six seconds of extension). The control group does not do any sports during this time.
The effect of 12 weeks of resistance training with different muscle tensions on mir-92, mir-204, mir-214, mir-233 and sclerostin in elderly women
Public title
The effect of sports activity on bones
Purpose
Prevention
Inclusion/Exclusion criteria
Inclusion criteria:
No surgery
Not having any heart disease
Not smoking and drinking alcohol
Not having a physical problem such as orthopedic and brain-nervous problems that prevent exercise.
Blood pressure > 110/180 as a criterion for exiting the study process
Menopause
Age range in the specified age range of 45 to 65
Exclusion criteria:
Lack of continuous exercise before starting the training program
Inability to exercise
Age
From 45 years old to 65 years old
Gender
Female
Phase
N/A
Groups that have been masked
No information
Sample size
Target sample size:
15
Randomization (investigator's opinion)
Randomized
Randomization description
It is block randomization. In order to perform block randomization, a specific code is assigned to each of the people under study (66 people). Then, blocks with a volume of 6 people, which have 3 exclusive codes, are defined. Two A codes, two B codes, and two C codes are identified. Each of these three codes represent each of the groups under study. From the combination and sequence of these codes in blocks of 6, different blocks are created. Then, using Stata software version 17 and using the command code egen block, blocks of 6 are selected by simple random method with placement. 11 blocks are selected using simple random placement method.
Blinding (investigator's opinion)
Not blinded
Blinding description
Placebo
Not used
Assignment
Parallel
Other design features
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
Research Ethics Committees of Lorestan University of Medical Sciences
Street address
km 4, Borujerd Road, Vice-Chancellor of Research and Technology, Lorestan University of Medical Sciences
City
Khorram Abad
Province
Lorestan
Postal code
418326599877
Approval date
2023-08-09, 1402/05/18
Ethics committee reference number
IR.LUMS.REC.1402.170
Health conditions studied
1
Description of health condition studied
The subject of study is not a disease
ICD-10 code
ICD-10 code description
ICD-10
Primary outcomes
1
Description
Increased serum sclerostin levels
Timepoint
48 hours before and after the last training session
Method of measurement
blood test
2
Description
decreased serum mir-92 levels
Timepoint
48 hours before and after the last training session
Method of measurement
blood test
3
Description
Increased serum mir-214 levels
Timepoint
48 hours before and after the last training session
Method of measurement
blood test
4
Description
decreased serum mir-233 levels
Timepoint
48 hours before and after the last training session
Method of measurement
blood test
Secondary outcomes
1
Description
noblood pressure
Timepoint
48 hours before and after the implementation of the research protocol
Method of measurement
nothrough a blood pressure monitor
Intervention groups
1
Description
Intervention group: Intervention group: In this research, according to the training protocol, there are two intervention groups. In the first group, the resistance training protocol is in the form of three periods of 12 repetitions with 75% of a maximum repetition and with two-minute rests between periods, with a duration of one second of muscle tension. (one second of flexion and one second of extension) and in the second group in the form of three periods of three repetitions with 50% of a maximum repetition and with two-minute rests between periods, with a duration of six seconds of muscle tension (six seconds of flexion and six seconds of extension). Was performed.
Category
Diagnosis
2
Description
Control group: Control group: In this research, there is a control group and they will not do any regular physical activity or exercise during the implementation of the protocol.
Category
N/A
Recruitment centers
1
Recruitment center
Name of recruitment center
Shahid Rahimi Hospital
Full name of responsible person
F azlollah Fathollahi
Street address
Azadi Square, Shahid Rahimi Hospital
City
Khorramabad
Province
Lorestan
Postal code
1236547896
Phone
+98 66 3342 5492
Fax
Email
f.fathollahi1363@gmail.com
Web page address
Sponsors / Funding sources
1
Sponsor
Name of organization / entity
Khoram-Abad University of Medical Sciences
Full name of responsible person
Bahram Rasoulian
Street address
Kilometer 4 of Borujerd Road, Vice-Chancellor of Research and Technology of Lorestan University of Medical Sciences
City
Khoramabad
Province
Lorestan
Postal code
326598741
Phone
+98 66 3312 0177
Email
research@lums.ac.ir
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Khoram-Abad University of Medical Sciences
Proportion provided by this source
100
Public or private sector
Public
Domestic or foreign origin
Domestic
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
Academic
Person responsible for general inquiries
Contact
Name of organization / entity
Khoram-Abad University of Medical Sciences
Full name of responsible person
Fazlollah Fathollahi Shoorabeh
Position
Assistant Professor
Latest degree
Ph.D.
Other areas of specialty/work
Sport Physiology
Street address
Kilometer 4, Borujerd Road, Medical Sciences Complex, Faculty of Medicine
City
Khormabad
Province
Lorestan
Postal code
1478523698
Phone
+98 66 3342 5492
Email
f.fathollahi1363@gmail.com
Person responsible for scientific inquiries
Contact
Name of organization / entity
Khoram-Abad University of Medical Sciences
Full name of responsible person
Fazlollah Fathollahi Shorabeh
Position
Assistant Professor
Latest degree
Ph.D.
Other areas of specialty/work
Physiology of exercise
Street address
Kilometer 4, Borujerd Road, Medical Sciences Complex, Faculty of Medicine
City
Khoramabad
Province
Lorestan
Postal code
1478523695
Phone
+98 66 3342 5492
Email
f.fathollahi1363@gmail.com
Person responsible for updating data
Contact
Name of organization / entity
Khoram-Abad University of Medical Sciences
Full name of responsible person
Fazlollah Fathollahi Shoorabeh
Position
Assistant Professor
Latest degree
Ph.D.
Other areas of specialty/work
Physiology of Exercise
Street address
Kilometer 4, Borujerd Road, Medical Sciences Complex, Faculty of Medicine
City
Khoramabad
Province
Lorestan
Postal code
1478523692
Phone
+98 66 3342 5492
Email
f.fathollahi1363@gmail.com
Sharing plan
Deidentified Individual Participant Data Set (IPD)
Yes - There is a plan to make this available
Study Protocol
Yes - There is a plan to make this available
Statistical Analysis Plan
Yes - There is a plan to make this available
Informed Consent Form
Undecided - It is not yet known if there will be a plan to make this available
Clinical Study Report
Yes - There is a plan to make this available
Analytic Code
Yes - There is a plan to make this available
Data Dictionary
Undecided - It is not yet known if there will be a plan to make this available
Title and more details about the data/document
The information is confidential and the results will be published as an article
When the data will become available and for how long
It does not have a specific yield
To whom data/document is available
Only the research team is allowed to access the data
Under which criteria data/document could be used
It is for the purpose of analyzing information.
From where data/document is obtainable
The documents are only available to the research team
What processes are involved for a request to access data/document
The documents are only available to the research team