Effectiveness of Ultrasound-Guided Internal Heat Acupuncture for Alleviating Posterior Lumbar Nerve Pain and Modulating Serum IL1-β, TNF-α, and PGE2 Levels.

This study is critical not just for increasing our understanding of PLNP, but also for developing novel, evidence-based therapies that might greatly improve the quality of life for those living with this terrible disorder.

A concealed, experimental, blinded, randomized clinical trial with a control group design of 30 patients enrolled between October 2023 and November 2023 and followed for 4 weeks

This will be conducted at The First People Hospital,Wuhan &trial assesor blind

Patients aged between 18-65 years diagnosed with PLNP and reporting a pain level of at least 4 on a 10-point visual analog scale (VAS) were eligible for the study. Exclusion criteria included pregnancy, current use of anti-inflammatory medications, history of spinal surgery, and contraindications to acupuncture.

1. UGIHA Group: Patients in the UGIHA group received acupuncture sessions twice a week for four weeks. A 0.3 mm × 40 mm disposable needle (DongBang Acupuncture Inc., Korea) was percutaneously inserted and advanced to a depth of 15-25 mm into the intervertebral foramen under real-time ultrasound guidance. The needle was then electronically activated to produce heat. Acupuncture points targeted specific regions of discomfort or dysfunction.(13) 2. Control Group: Participants in the control group received non-therapeutic ultrasound therapy sessions twice a week for four weeks. The ultrasound therapy was administered without the application of heat and did not involve needle insertion

1. Primary Outcome: Pain severity was assessed using a 10-point visual analog scale (VAS) at baseline, after the 4-week intervention period, and during follow-up visits. 2. Secondary Outcomes: Serum levels of IL1β, TNF-α, and PGE2 were measured before and after the treatment period using established biochemical assays.

Participants who fulfilled the inclusion criteria were selected convenient sampling technique and were then allocated randomly to Group A and Group B using lottery method. This distribution process is hidden between participants and researchers. This was done by a research assistant who did not participate in any further research.

This study was double-blinded. The outcome assessor who was blinded to the therapy group was recruited to take readings at pre-treatment and post-treatment values. And the patients were also blinded as they didn’t know they all have the same disorder and different techniques had been given to these patients.

Effectiveness of Ultrasound-Guided Internal Heat Acupuncture for Alleviating Posterior Lumbar Nerve Pain and Modulating Serum IL1-β, TNF-α, and PGE2 Levels.

When the trial has been completed after the end November 2023.The data will be available for the future use and after the completion of the trial when it get published approximately after the 4 weeks in the end of the November 2023.The summary will be available after the article get published

It will be available to all teaching institue and hospital for the better cure of the patient and more over it will be avilable for the researcher as wel

Only for the research and for the benefits of the public

Daojing Su Orthopedic Rehabilitation(1 Ward) of Shiyan Taihe Hospital affiliated to Hubei University of Medicine 32 renmin south road,maojian district,shiyan city,hubei province 605278189@qq.com

By application sent to 605278189@qq.com