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Study aim
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Comparison of the effect of Endotracheal suction on hemodynamic parameters and arterial blood gases in two methods of endotracheal N-acetylcysteine and normal saline in intubated patients under mechanical ventilation
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Design
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Clinical trial with a control group, with factorial groups, single blind, randomized, phase 3 on 90 patients. A lottery method is used for randomization.
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Settings and conduct
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The location of the study is the intensive care units of Amir al-Mominin Ali Hospital, Zabul City.
The study is a single-blind study of the type of participants.
way to do:
At first, 5 minutes before the start of endotracheal suction, an arterial blood sample is taken from all patients. Before intratracheal suction, hemodynamic parameters are controlled. immediately after recording the hemodynamic parameters, the endotracheal suction procedure is performed. 25 minutes after endotracheal suction, arterial blood samples are taken from patients again, and hemodynamic parameters are controlled at intervals of 1, 5 and 30 minutes after endotracheal suction.
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Participants/Inclusion and exclusion criteria
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Inclusion criteria: intubated patients under mechanical ventilation and stable hemodynamic conditions
Exclusion criteria: lack of intubation and unstable hemodynamic conditions of patients
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Intervention groups
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Endotracheal suction with
1- With normal saline: Endotracheal inoculation of 3 ml of normal saline serum
2- With N-acetyl cysteine: Endotracheal inoculation of 2 ml of N-acetyl cysteine 20%
3- Without solution inoculation: Endotracheal suction is performed routinely without solution inoculation.
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Main outcome variables
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Arterial blood gases include pH, Saturation of Peripheral Oxygen, relative pressure of carbon dioxide, relative pressure and bicarbonate level.
Hemodynamic parameters include heart rate, respiration rate, blood pressure and arterial saturation.