Safety and Effect of Celastrol Supplementation on Rate of Union in Femur and Tibia Fracture Patients

Inclusion criteria:

Willingness to cooperate and complete the informed consent form by the patient 18 to 60 years old Closed fracture of femur and tibia Body mass index ≥ 35 kg/m2 SSI score between 9 and 15 Candidates for open fixation surgery Move without help from 2 months before the fracture No need for other formulas due to a special problem (kidney, lung, liver, etc.) Non malabsorption syndrome Non parathyroid gland disorders Absence of hepatic encephalopathy and liver cirrhosis Non myocardial infarction in the last month Non uncompensated congestive heart failure Non lower limb amputation Non angina symptoms Non Chest pain or shortness of breath (including severe COPD) Non kidney failure (blood creatinine lower than 1.2 mg/dL in men and 1.1 mg/dL in women/ GFR≥90) Non Hepatic failure (AST ≤ 109 U/l, ALT ≤ 97 U/l and INR ≤ 1.5) No metastatic cancer No infection and sepsis No uncontrolled blood pressure No cognitive impairment (3MS score > 73) Not taking drugs that affect bone metabolism, such as calcitonin, bis-phosphonates and corticosteroids Not taking albumin solution before and after surgery Not taking supplements or formulas that strengthen the immune system including : Arginine, glutamine, vitamins C and E, selenium, zinc or omega-3 fatty acids during the last 2 weeks before the start of the intervention No allergy or lactose intolerance

Exclusion criteria:

Target sample size: 70