Evaluation of the effect of magnesium sulfate on the intensity and duration of pain in renal colic patients by a double-blind clinical trial in the case and control groups

Considering drug shortages and the prevalence of narcotic drugs in pain relief, this study is designed to reduce the need for narcotic drugs and define new drug combinations to relieve the pain of renal colic patients.

A controlled, parallel-group, double-blind, randomized, phase 3 clinical trial on 160 patients, to randomize an emergency medicine specialist.

This double-blind randomized clinical trial was designed to investigate the effect of intravenous magnesium sulfate in relieving pain in patients referred to the emergency department of Imam Khomeini Hospital (ED) following renal colic. Before entering the study, all patients will be given appropriate explanations about the study and sign the informed consent to enter the study, they are free to refuse to participate in the study and withdraw from the study. The place of research is Imam Khomeini Hospital in Ahvaz.

The inclusion criteria for this study are: clinical diagnosis of renal colic, age between 18 and 55 years, and pain intensity > 5 based on visual analog scale (VAS). Exclusion criteria were as follows: history of seizures. any heart, liver, kidney or metabolic disease; Fever (oral temperature > 38°C), systolic blood pressure less than 90 mmHg, pregnancy, acute abdomen, use of pargoric drug 3 hours before going to the emergency room, history of drug addiction or allergy and use of calcium channel blockers, recent gastrointestinal bleeding, Active peptic ulcer or recent perforation

30 mg of ketorolac plus 15 mg/kg of 50% magnesium sulfate in 500 ml of normal saline is injected in 15 minutes.

Systolic blood pressure at 0, 30 and 60 minutes Diastolic blood pressure at 0, 30 and 60 minutes Pain intensity at 0, 30 and 60 minutes Pulse rate at 0, 30 and 60 minutes

Patients are randomly divided into two groups using the balanced block randomization technique. For this purpose, blocks of four are prepared, the name of the witness is written on two sheets and the interventionist's name is written on the other two sheets. The sheets are piled up and placed in the container, and one sheet is pulled out for each patient without placing it. Then four sheets are returned to the container and this process is repeated until the sample volume is reached.

The student researcher conducting the research who is responsible for data collection and the patients participating in this research were kept blinded. The emergency doctor and nurses know the difference between the control group and the intervention group. Patients will be adequately explained about the trial and will be excluded from the study if they do not wish to participate. After the patient's discharge, the research student will be informed about the medicine received by the patient.