We designed the present study to investigate whether pre-emptive use of gabapentin 300 mg orally could reduce postoperative pain, nausea and vomiting after hysterectomy. A total of 140 patients whom were candidate for elective abdominal hysterectomy randomly assigned to one of two groups according to the method of treatment: gabapentin or placebo in a double-blind manner before hysterectomy. The inclusion criteria were ASA class I and II, nonmalignant status (benign gynecologic disease), general anesthesia, and body mass index (BMI) of 20 to 30 kg/m2. The exclusion criteria were known allergy against gabapentin, motion sickness, psychiatric disorder, substance abuse, duration of surgery excess 3 hours. Gabpentin or placebo is given to patients about 1 hour before induction of anesthesia. Postoperatively, the pain was assessed on a visual analogue scale (VAS) at 1, 4, 8, 12 and 24 hours at rest. Acetaminophen intravenously was used to treat postoperative pain on VAS score. Total acetaminophen and anti emetic drug consumption in the first 24 hours after surgery was also recorded.