Comparison the effect of dexmedetomidine with remifentanil on postoperative pain after lumbar laminecthomy with general anesthesia

The purpose of this study will be to assess comparison the effect of dexmedetomidine with remifentanil on postoperative pain after lumbar laminectomy with general anesthesia

Clinical trial with two arm parallel groups, randomised trial with double blinded assessment. Study phase will be 3-2.

In Urmia Imam Khomeini hospital operating room, pain score will be measured by visual analog scale, whose utilization will be previously taught to the patient recovery, as well as 6, 12, and 24 hours after surgery by trained nurses who will be unaware of the group of each patient.

inclusion criteria: age group of 20 to 60 years old, American Society of Anesthesiologists class I and II, elective lumbar laminectomy exclusion criteria: hypertension, history of bradycardia (heart rate below 50), those who had allergies to the used medications, gastritis, kidney and lung disease, psychiatric problems, drug addicts, and patients treated with beta-blockers, methyldopa, monoamine oxidase inhibitors, analgesic drugs, and those with body mass index above 25 kg/m2

Intervention group dexmedetomidine:Before anesthesia induction, 0.3 μg/50kg/min dexmedetomidine will be injected using a syringe pump for 10 minutes. During surgery 0.01to 0.02 μg/kg/min dexmedetomidine will be used. Intervention group remifentanil: Before anesthesia induction, 0.01 μg/kg/min remifentanil will be injected using a syringe pump for 10 minutes. During surgery 0.01to 0.2 μg/kg/min remifentanil will be used.

pain

Patients will be randomly assigned into two groups of Dexmedetomidine (group D) and Remifentanil (group R) using Random Allocation Software 2.0, and the target codes will be written and placed in sealed envelopes with sequential allocation using double-blind method.

The anesthesiologist will be unaware of which patient will be assigned to which group. Syringes will be identical and only the nurse will knew about the contents of each of them, and finally, after collecting information from the anesthesia residents, the anesthesiologist will be informed of the group each patient will be assigned to.