Effect of flaxseed oil supplementation on Omentin, Chemerin and Thromboxane B2 levels in Patients with Coronary Artery Disease

1- Determination and comparison of the effect of flaxseed oil and placebo on serum Omentin in patients with coronary artery disease 2- Determination and comparison of the effect of flaxseed oil and placebo on serum Chemerin in patients with coronary artery disease 3- Determination and comparison of the effect of flaxseed oil and placebo on serum Thromboxan B2 in patients with coronary artery stenosis

In this double blind randomized trial (randomized randomized trial), 44 patients with coronary artery stenosis (coronary angiography confirmation) will be included in the study based on inclusion criteria and no admission for 2 months.

Among those who are referring to the Shahid Madani Hospital in Tabriz, qualified individuals are given a brief explanation for the study. People who agree to participate in the study are asked to start taking either new medication or Investigate the onset of any side effects as a result of the use of flaxseed oil supplementation. To minimize the effects of confounding factors, individuals are randomly assigned to complement and placebo groups for age, sex, BMI, and received drugs (lipid lowering and blood pressure). The researchers and participants of the study were blinded in this study. The blindness is such that the manufacturer of the plant has provided a code for supplementation and a code for the placebo, and this code is maintained by the expert responsible for the manufacturer's factory until the end of the study.

Entry Requirements: 1) age range of 60-30 years 2) BMI ranges from 35 to 25 kg / m 2 3) Proof of stenosis of 50% ≤ minimum in one of the major coronary arteries through angiography 4) willingness and ability to cooperate in the plan Conditions for not admitting to study: 1) Myocardial Infarction, Cardiac Functional Cardiac Disorders 3 and 4 (FC III, IV), Cardiac valve disease  Diabetes and any other chronic inflammatory disease 2) Use of suppressive drugs or vitamin supplements and antioxidants, fish oil or any type of supplementation of omega-3 3) Use more than two servings of fish per week 4) Use of weight loss medications or weight loss surgery 5) Smoking or substance abuse 6) Pregnant or breastfeeding

The intervention group received 200 cc milk with 2.5% fat, prepared with flaxseed oil (containing 2 g of alpha linolenic acid) and the placebo group received the same amount of non-fat sterilized milk for 2 months and the fat in both groups By diet design, each person will be adjusted.

Omentin, Chemerin, Thromboxane B2

Tabriz University Of Medical Sciences

Randomization method: Block randomization

Participants and main investigators have been blinded.

Demographic and primary outcomes data of participants

Accessibility to data is possible 1 year after publication.

Researchers who are working in academic institutes.

Only observation of documents is allowed; Analysis and use of data is not possible.

Dr. Mohammad Alizadeh, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, 09141894102, mdalizadeh@tbzmed.ac.ir 2. Zahra Mollarasouli , Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, 09370258717, zrasouli92@yahoo.com

The applicator can send a request to the person responsible for the study by email and within 20 days the document will be sent to the requesting person.