The purpose of the present study is to investigate the painkilling effect of morphine plus placebo in comparison with morphine plus tamsulosin. To do this research, we are going to carry out a randomized, double-blind study over 200 patients aged 18 to 55 presenting with acute renal colic to the emergency department of Imam Reza Hospital. Patients with one of the following criteria will be excluded from the study: opium addiction, pregnancy, any history of renal or hepatic disease and bilateral renal stones. After making sure that all of the inclusion criteria exist, the information about medicines’ advantages and side effects are provided to the participants and a written consent is obtained from the patients in case they agree to participate in the study. Then, the patients will be divided into two groups of A and B at a random selection without the researcher’s interference (based on the randomized block method using 200 Sequencing provided by statistics expert). Before the administration of the chosen drug, the patients are asked to determine their pain level based on the visual analogue scale (VAS) using the ruler of VAS which is given to them. Group A patients will be treated with 0.1 mg/kg IV morphine plus 0.4 mg of oral tamsulosin produced by Tasnim pharmaceutical company and Group B patients will be treated with the same dose of IV morphine plus placebo (empty tablet shells provided by Tasnim pharmaceutical Co., having the same shape as tamsulosin tablets, filled with starch).
After 30 minutes, 2, 4 and 6 hours of the drug administration, the patients’ pain level will be evaluated again based on VAS using the ruler of VAS that has been given to the patients. Finally, data collected from the two groups will be compared and analyzed.