The goal of this study is to evaluate the effect of vitamin B12 and folate supplementation on serum homocysteine, megaloblastic anemia status, hypertension and life quality of M.S patients. This study is a double-blinded randomized clinical trial in which blinding will be conducted for the patients and the researcher. Patients will be divided into two groups (each group consists of 25 patients), including the intervention group and the placebo group. Both groups of patients will be selected randomly among relapsing-remitting M.S patients aged 20 - 40 years old. Exclusion criteria includes some conditions that can affect the variables in the study, like some nuerological disorders and vitamin B12 consumption during the last six months. Blood pressure, CBC blood test, serum homocysteine and life quality questionnaire will be measured in both groups before starting the interventions. Interventions in the intervention group consist of 5mg oral folate supplement (once a day) for two months and 3 doses of 1mg vitamin B12 injective supplement; the first dose will be injected immediately after taking blood samples from the patients, the second dose one month after the first injection, and the third dose one month after the second injection. And in placebo group, interventions include pills made from strach similar to folate supplement and normal saline injection (doses are similar to those of the intervention group). At the end of the interventions, CBC blood test, serum homocysteine level, Life quality and blood pressure, will be measured in both groups and the results will be analyzed.