Labor pain is often severe. Unrelieved labor pain can have an adverse effect on both the mother and the infant. The aim of this study was to compare Hoku point (LI4) acupressure and San-Yin-Jiao (SP6) acupressure in labor pain and length of delivery time in nulliparous women in Iran hospital. A randomized clinical trial was performed on 60 nulliparas women who were at the beginning of active phase of labor (4 cm dilatation of cervix). The women were randomly assigned to one of the two groups. The Sanyinjiao group received acupressure at Sanyinjiao points for 20 minute during contractions on two feet. In the Hoku group, acupressure served in the same manner at Hoku points on two hands. Data were collected by means of questionnaires. Labor pain was measured with visual-analogue scale: before the intervention and after the intervention in 4, 6, 8 and 10 cm cervical dilation. Length of delivery time was calculated in two stages: from 4 cm cervical dilation to full cervical dilatation and full cervical dilatation to the delivery. Inclusion criteria being at the beginning of active phase of labor, gestational age between 38-42 weeks, single fetus, cephalic presentation and primiparous women. Exclusion criteria: any psychotic and diagnosed anatomic disorder, chronic diseases, any inflammation in the acupressure region, polyhydraminus and oligohydramimus ,fetal movement reduction, intrauterine growth retardation, fetal death, CPD, history of infertility, abnormal pattern of fetal heart rate , and participants who were taking psychotherapeutic drugs were excluded. Primary outcome is labor pain and Secondary outcome is duration of the active phase of labor.