The effects of BlackBerry (Morus nigra L.) consumption on serum concentration of lipoproteins , APO A1 , APO B and hs – CRP and blood pressure in dyslipidemic patients

object: The effects of BlackBerry (Morus nigra L.) consumption on serum concentration of lipoproteins , APO A1 , APO B and hs – CRP and blood pressure in dyslipidemic patients. This study is a randomized, single-blind,multiple center with control group in the phase 3 of clinical trial. inclusion criteria: ; informed consent; dislipidemia ( cholesterol > 200 mg/dl and LDL > 100 mg/dl );BMI between 20-35;age between 18-65;no consumption of any drugs affecting lipid metabolism; no consumption antioxidant supplements of at least one month prior to study entry and during study; lack of any systematic disease,inflammation ,choronic or liver and kidney disease;no pregnancy or lactation;lack of sensivity to the blackberry. Exclusion criteria: not wanting Collaboration; changes in food pattern ; systematic or choronic disease during the study; LDL higher than 160 mg/dl and necessity to medication under specialist .72 Eligible patients randomaly divided into two groups, intervention and control groups;individuals in intervention group receive 300 gr BlackBerry daily for 8 weeks and individuals in control group are asked to continue their usual diet without eating berries. The primary expected outcomes are changes in serum level of lipoproteins,Apo A1,Apo B,hs-CRP and blood pressure compared with baseline in the intervention group and the control before and after of intervention.

Tehran University of Medical Sciences