Effect of Ginger supplementation on serum lysophosphatidic acid,lipid profile, Total Antioxidan capacity and high-sensitivity C-reactive protein in atherosclerotic patient.
atherosclerosis is one of the main problem in growing country. ginger is natural herb that used by many people with foods and tea. recently some studies shown that ginger have noninflammatory and antioxidant properties.
1- The objectives were: to determine the levels of Lysophosphatidic acid, lipid profile, Total Antioxidan capacity and high-sensitivity C-reactive protein in control and treated group( consuming ginger).
2- Design of the study :initially 60 patients with atherosclerosis determined by a Cardiologist, dividing patients into two groups of 30 people, including patients taking ginger and the control group (patients taking placebo), getting consent and interview them about their general profile and clinical records of patients, measuring height and weight and determine the Body Mass Index (BMI) of patients. Provided dry ginger powder and Preparation capsules containing 800 mg of powdered ginger rhizome. Placebo containing wheat flour is provided in a similar way and in the same form and color.To create the aroma in the placebo capsules, the capsules is placed near the ginger powder for 2 weeks and then packed in cans similar. Patients take , 1600 mg of powdered rhizome of ginger or placebo ( 1 capsule of 800 mg before lunch and 1 capsule of 800 mg before dinner). The intervention will continue for 2 months. then 5 ml of blood is taken from each groups. And then separate serum samples.Serum samples were stored at -70 ° C and then studied markers are measured by the spectrophotometric methods and ELISA.
3-Participants including major eligibility criteria: Inclusion criteria included: all patients (men and women) with atherosclerosis eligible for medical treatment by Cardiologist; and age 40 to 70 years.
exclusion criteria including: those patient consuming below 80% of supplement; and change drugs in during intervention.
4- Interventions include: the use of capsules containing 800 mg of powdered ginger rhizome and a placebo containing wheat flour.
5- The main outcome measures variable included: Lysophosphatidic acid, lipid profile, Total Antioxidant capacity and high-sensitivity C-reactive protein.