Comparison of traditional medicines of Rheum Palmatum versus Paeonia Officinalis and Mefenamic acid on primary dysmenorrhea : a randomized clinical trial

The aim of this study is to compare Iranian herbal medicines of Rheum palmatum versus Paeonia Officinalis and Mefenamic acid on the duration and severity of primary dysmenorrhea as a randomized clinical trial.The study is interventional and double blind.Patients and researcher will be unaware of the contents of the drug package.The sample size is 35 in each group and the study will be done in three groups. Firstly, a brief description of the people who have the criteria for entering the study is taken. After understanding the type of dysmenorrhea, duration and severity, history of previous illnesses and drug use, people who have moderate to severe dysmenorrhea are to be tested. The decision criterion for measuring pain intensity is based on the Visual Analog Scale (VAS) and (VMSS).The population of this study is students living in dormitories of Tabriz University of Medical Sciences. Selection of patients will be available for inclusion in the study. This will continue until the sample size is sufficient.Each patient will be studied in three consecutive cycles. During the first cycle (control cycle), the placebo will be given to patients and patients will be asked to respond to the degree of severity and duration of the pain, along with other symptoms that are in the questionnaires and forms. During the second and third cycles of the capsule containing the Rivand root into the test group one, the capsule containing peony was given to the experimental group 2 and capsule containing MEFNAMIC ACID to the third group.The necessary information on the way the drug is used by the researcher is provided orally and in writing to the patient. The dosage is given from the day before the menstruation up to 5 days later, as an 8-hour period and followed up for three consecutive cycles.If the symptoms of a patient's pain are resolved sooner, the drug will continue until one day after the symptoms are resolved. If within 3 months, the patient has not stayed in the study or within 3 months of one of the conditions, including underlying illness, heart disease or any metabolic problem was fixed, or the patient used another medicine to relieve pain, will be excluded. Inclusion criteria: 18_35years old Regular menstruation Severity of pain moderate to severe Exclusion criteria: Pregnancy Uterine infections Irregular mense

Tabriz University of Medical Sciences