Determining the effect of a combination of Promethazine, Dexamethasone, and Ondansetron in comparison with Haloperidol, Dexamethasone, Ondansetron for prophylaxis of nausea and vomiting after laparoscopic bariatric surgery in Sina hospital, 2018.

Comparing antiemetic effect of Promethazine, Dexamethasone, Ondansetron and Haloperidol, Dexamethazone, Ondansetron after laparoscpoic bariatric surgery.

This is a two arm parallel double blind clinical trial. The participants are selected from patients aged 18-65 years who are candidates for laparoscopic bariatric surgery and have the inclusion criteria. Eighty patients are divided to two equal groups through simple randomization using a random number table. Group A receives a three-drug regimen (Ondansetron 4 mg, Dexamethasone 8 mg and Haloperidol 2 mg) and group B receives Ondansetron 4 mg, Dexamethasone 8 mg and Promethazine 25 mg for PONV prophylaxis.

This is a randomized two arm parallel double blind clinical trial in Sina hospital.Patients and researcher are not informed of each patient's intervention group. Post operative follow up is done by researcher who knows the patient's names but not the antiemetic used.

Inclusion criteria: • Age 18-65 years • BMI>30 Kg/m2 • ASA class I or II Exclusion criteria: • Contraindication to dexamethasone, ondansetron, haloperidol, and promethazine • Use of illicit drugs, hormonal anti-inflammatory drugs, and antiemetics within 24 hours before surgery • Serious adverse reaction like shock, cardiac arrest, and hemorrhage requiring transfusion • History of prolonged QT

Group A receives a three-drug regimen (Ondansetron 4 mg, Dexamethasone 8 mg and Haloperidol 2 mg) and group B receives Ondansetron 4 mg, Dexamethasone 8 mg and Promethazine 25 mg.

Post operative nausea and vomiting score at recovery room, 6 and 24 hours after surgery, First time of antiemetic prescription after surgery until 24 hours, Accumulative dose of antiemetics prescription after surgery until 24 hours, Recovery time

Tehran University of Medical Sciences

This is randomized double blind clinical trial.80 patients were assigned in two group of 40 people according to random numbers.Patients and researcher have no data of this randomization.

This is double blind clinical trial.Patients and researcher are not informed of randomization. Questionnaire designed in three pages; Page 1 including patients' name and group (A or B) which is selected by randomization,is recorded at operation room by Anesthetic technician.On the next pages which include demogarphic and post operative data, only patients' name is recorded. Pages 2 and 3 will be filled in by researcher who doesn't know patients' group. Page 1 will be kept in a separate folder and pages 2 and 3 will be kept together in another folder. Finally, we'll open the two folders and sort the pages according to pharmacological groups.