Comparison of Efficacy of Ozone Therapy with Routine Medical Treatment On The Severity Of Allergic Rhinitis.

The Purpose of this Study is to compare the Effectiveness of Ozone Therapy with Routine Medical Treatment in Patients with Allergic Rhinitis

Parallel, single-blind, randomized clinical trial

40 Patients with Allergic Rhinitis that were referred to the manager's clinic of Kashan University of Medical Sciences, Kashan, Iran will be selected in the study. Patients will be divided into two groups. Patients of the control group will recieve antihistamine. Patients of the treatment group will recieve antihistamine and undergo ozone therapy. . The changes of disease severity will determine and compare in patients at the beginning and at the end of the intervention.

Inclusion criteriaes: Having Allergic Rhinitis and age over 12 years. Exclusion criteriaes: Any Respiratory and non-respiratory inflammation such as infection, Recent massive surgery, severe pulmonary or renal disease, alcohol abuse, sever addiction, uncontrolled diabetes, cancer, autoimmune diseases

Patients will be divided into two groups. So patients in the treatment group will undergo ozone therapy and classical allergy treatment (oral Cetirizine10 mg daily plus nasal Mometasone spray every 12 hours in every nasal cavity), and patients in the control group will receive only Antihistamines (classical treatment). The physician will examine the patients and based on the clinical and paraclinical findings will fill the questionnaire for any of them. Patients will undergo any treatment for 3 months. Paraclinical diagnosis is performed by doing a specific IgE measurement for types of inhaler allergens by ELISA. For each patient, at least 15 allergens will check. Ozone therapy is performed in the form of minor autohemotherapy, in which about 20 doses of 10-20 micrograms of ozone with 10 ml of peripheral whole blood of the patient are mixed and injected intramuscularly in daily intervals. The effect of treatment in both groups will be evaluated by comparing the severity of the disease initially, and after 3 months at the end of the treatment.

The severity of the disease in both groups will be determined and compared at the beginning and at the end of the study.

research assistance of kashan university of medical science

After specifying the sample size, the first four blocks of A and B letters are formed (6 blocks). Then, each of the blocks is numbered 1 to 6 and based on the selected numbers from random numbers table, we form a sequence of blocks, in which the letters A and B are located, and then randomly one of the letters are considered as the drug group and the other letter as the control group. This method is referred to as "Termuted Blocked Randomization".

Since this is a single-blind study, our blindness would be single-blinded.