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Study aim
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The effect of vitamin D supplementation on anthropometric indices and Leptin serum level in women with polycystic ovary syndrome treated with low calorie diet
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Design
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In this study, 40 patients were chosen who have inclusion criteria. participant were randomly allocated to two intervention and placebo groups and given code to each of theme.
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Settings and conduct
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A randomized double-blind clinical trial was conducted in women with polycystic ovary syndrome and vitamin D deficiency who referred to Izadi Gynaecology clinic of Qom.
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Participants/Inclusion and exclusion criteria
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Inclusion criteria: The desire to participate in the study, aged 18-40 years, Patients with PCOS according to Rotterdam criteria, BMI between 25 to 40, Serum vitamin D levels less than 20 ng /ml, not using weight loss diet or vitamin D supplement over the last 3 months, not using hormone therapy, not using certain drugs including weight loss drugs or multivitamin supplements mineral, not smoking, not doing heavy and professional exercise. Exclusion criteria: individuals with diabetes, Cardiovascular disease, Liver, kidney, thyroid and para- thyroid, Cushing's syndrome, osteomalacia, changes in physical activity, Non-compliance with diet and supplementation.
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Intervention groups
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Forty women with polycystic ovary syndrome and vitamin D deficiency randomly assigned to intervention (20 participants) and control (20 participants) groups. Participants in intervention group received low-calorie diet + 50,000 IU/week oral vitamin D3 and participants in control group received low-calorie diet + placebo/week (including paraffin) for 12 weeks.
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Main outcome variables
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Serum 25(OH)D, leptin serum level, weight, Body Mass Index,waist circumference, hip circumference, percent of body fat, percent of free fat mass