The investigating of the effect of curcumin and zinc co-supplementation on glycemic measurements, lipid profiles, inflammatory and antioxidant biomarkers in pre-diabetic patients

The determining of the effect of curcumin and zinc co-supplementation on glycemic measurements, lipid profiles, inflammatory and antioxidant biomarkers in pre-diabetic patients

a double-blind randomized controlled trial/ factorial design/ 4 parallel groups: (N=21)

84 patients referring to Yazd Diabetes Specialty Clinic who meet the inclusion criteria will be randomly divided into 4 groups by random sampling. General Characterization and the assessment of anthropometric, diet, Weight loss, physical activity, and biochemistry will conduct for each patient. After 3 months of supplementation, the above assessment will be re-evaluated.

Inclusion criteria: Both genders age: 18-50 years, prediabetic patients, BMI=25-35 No use of blood glucose-lowering drugs, written informed consent from patients Exclusion criteria: Having a history of gestational diabetes,- Pregnancy or lactation in women, Use of multivitamin-mineral supplements from three months before and during the intervention, a history of weight loss surgery in the last year, weight loss plan in the last 3 months, Sensitivity to supplementation or non-compliance during the intervention, Simultaneously participate in another project, Unwillingness to continue cooperation

pre-diabetes patients

insulin, fasting glucose, HbA1c, insulin resistance, insulin sensitivity, beta-cell function, serum triglyceride, serum total cholesterol, serum LDL-C, HDL-C, ALT, AST, TAC, MDA, serum zinc, IL-1B, CRP, hs-CRP,

In order to prevent selection bias from occurring after randomization, the concealment allocation method will be used to assign binary codes to each individual.

Before starting the study, a person other than the researchers will code the packages including two cans according to the number of participants in the study to keep the researcher informed about the type of pills received by each group. Each individual is delivered a pack including two cans. On each can, how to use the pills will be explained. Package 1 will contain (can1: placebo for curcumin supplement (bb), and can 2: zinc supplement (AA)); package 2 will contain (can1: placebo for zinc supplement (aa), and can 2: curcumin supplement (BB)); Package 3 will contain (can 1: zinc supplementation (AA) and can 2: curcumin supplementation (BB)), package 4 will contain (can 1: placebo for curcumin supplement (aa), and can 2: placebo for zinc supplement (bb)).

all data is related to primary and secondary outcome, will be reported.

After the manuscript publication.

After publication, it will be possible for everyone.

Using the documentation with citation 1- To conduct similar and extensive research 2- To use the method of a project 3. To write systematic Review and meta-analysis articles

1- Refer to the Library of Ahvaz Jundishapur University of Medical Sciences 1-Refer to the Library of Yazd University of Medical Sciences 3- Email to Maryam Azdari: azhdari_mar@yahoo.com)

Everyone can use the data Referring to the library of the above-mentioned universities or by the emailing, for received data by email, it will be necessary to explain the reason for the using the data completely and clearly. He/she will be received within a maximum of one week.